| Literature DB >> 18005746 |
John P Moore1, Per Johan Klasse.
Abstract
The chemokine receptor CCR5 is the most important entry coreceptor for HIV-1 in vivo. Its chemokine ligands, including CCL3L1, efficiently inhibit infection by receptor blockade and downmodulation. However, in Nature Immunology, Dolan et al. (2007) present a large human-cohorts study that identifies entry-independent, CCR5-CCL3L1-dependent effects on cell-mediated immunity as a strong correlate of pathogenesis and point to additional influences of the CCR5-CCL3L1 axis on disease progression through undefined mechanisms.Entities:
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Year: 2007 PMID： 18005746 DOI： 10.1016/j.chom.2007.10.005
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023