Literature DB >> 18000759

Rho GTPases: functions and association with cancer.

Saskia I J Ellenbroek1, John G Collard.   

Abstract

Rho GTPases are small proteins that act as binary molecular switches in a wide range of signalling pathways upon stimulation of cell surface receptors. Three different classes of regulatory proteins control their activity. In the activated state small GTPases are able to bind a variety of effector proteins and initiate downstream signalling. Rho GTPases regulate important cellular processes ranging from cytoskeletal remodelling and gene expression to cell proliferation and membrane trafficking. Therefore it is not surprising that deregulated Rho signalling can contribute to disturbed cellular phenotypes in a wide range of diseases. The main focus of this review will be the diversity of functions of Rho GTPases and the effects of aberrant Rho GTPase signalling in various aspects of cancer.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18000759     DOI： 10.1007/s10585-007-9119-1

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  161 in total

1.  Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass.

Authors:  Chun Xiang Sun; Gregory P Downey; Fei Zhu; Adeline L Y Koh; Herman Thang; Michael Glogauer
Journal:  Blood       Date:  2004-08-12       Impact factor: 22.113

Review 2.  The ras protein family: evolutionary tree and role of conserved amino acids.

Authors:  A Valencia; P Chardin; A Wittinghofer; C Sander
Journal:  Biochemistry       Date:  1991-05-14       Impact factor: 3.162

3.  Rac1 is required for the formation of three germ layers during gastrulation.

Authors:  K Sugihara; N Nakatsuji; K Nakamura; K Nakao; R Hashimoto; H Otani; H Sakagami; H Kondo; S Nozawa; A Aiba; M Katsuki
Journal:  Oncogene       Date:  1998-12-31       Impact factor: 9.867

4.  Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.

Authors:  P L Hordijk; J P ten Klooster; R A van der Kammen; F Michiels; L C Oomen; J G Collard
Journal:  Science       Date:  1997-11-21       Impact factor: 47.728

5.  Rho GTPases as modulators of the estrogen receptor transcriptional response.

Authors:  L F Su; R Knoblauch; M J Garabedian
Journal:  J Biol Chem       Date:  2000-11-01       Impact factor: 5.157

6.  p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.

Authors:  Gregg A Wildenberg; Michael R Dohn; Robert H Carnahan; Michael A Davis; Nichole A Lobdell; Jeffrey Settleman; Albert B Reynolds
Journal:  Cell       Date:  2006-12-01       Impact factor: 41.582

7.  RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.

Authors:  Anne Hakem; Otto Sanchez-Sweatman; Annick You-Ten; Gordon Duncan; Andrew Wakeham; Rama Khokha; Tak W Mak
Journal:  Genes Dev       Date:  2005-08-17       Impact factor: 11.361

8.  Rho GTPases have diverse effects on the organization of the actin filament system.

Authors:  Pontus Aspenström; Asa Fransson; Jan Saras
Journal:  Biochem J       Date:  2004-01-15       Impact factor: 3.857

9.  Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior.

Authors:  E E Sander; J P ten Klooster; S van Delft; R A van der Kammen; J G Collard
Journal:  J Cell Biol       Date:  1999-11-29       Impact factor: 10.539

10.  Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

Authors:  G C Zondag; E E Evers; J P ten Klooster; L Janssen; R A van der Kammen; J G Collard
Journal:  J Cell Biol       Date:  2000-05-15       Impact factor: 10.539
View more
  111 in total

1.  The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.

Authors:  Kristi Bray; Cord Brakebusch; Tracy Vargo-Gogola
Journal:  Small GTPases       Date:  2011-09-01

Review 2.  The Rho guanine nucleotide exchange factors Intersectin 1L and β-Pix control calcium-regulated exocytosis in neuroendocrine PC12 cells.

Authors:  F Momboisse; S Ory; M Ceridono; V Calco; N Vitale; M-F Bader; S Gasman
Journal:  Cell Mol Neurobiol       Date:  2010-11-19       Impact factor: 5.046

Review 3.  Role of rho kinase in the functional and dysfunctional tonic smooth muscles.

Authors:  Márcio A F de Godoy; Satish Rattan
Journal:  Trends Pharmacol Sci       Date:  2011-04-15       Impact factor: 14.819

4.  Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8.

Authors:  Yoshihiro Yui; Kazuyuki Itoh; Kiyoko Yoshioka; Norifumi Naka; Motonobu Watanabe; Yoshimi Hiraumi; Hiroshi Matsubara; Ken-ichiro Watanabe; Kazumi Sano; Tatsutoshi Nakahata; Souichi Adachi
Journal:  Clin Exp Metastasis       Date:  2010-09-26       Impact factor: 5.150

5.  miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.

Authors:  Seong-Yeon Park; Jung Hyun Lee; Minju Ha; Jin-Wu Nam; V Narry Kim
Journal:  Nat Struct Mol Biol       Date:  2008-12-14       Impact factor: 15.369

6.  The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis.

Authors:  Donita C Brady; Jamie K Alan; James P Madigan; Alan S Fanning; Adrienne D Cox
Journal:  Mol Cell Biol       Date:  2008-12-08       Impact factor: 4.272

7.  Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling.

Authors:  Yaqin Zhang; Leslie A Rivera Rosado; Sun Young Moon; Baolin Zhang
Journal:  J Biol Chem       Date:  2009-03-06       Impact factor: 5.157

8.  Timing is everything: Rac1 controls Net1A localization to regulate cell adhesion.

Authors:  Heather S Carr; Jeffrey A Frost
Journal:  Cell Adh Migr       Date:  2013-06-10       Impact factor: 3.405

9.  Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.

Authors:  Zurab Surviladze; Anna Waller; Yang Wu; Elsa Romero; Bruce S Edwards; Angela Wandinger-Ness; Larry A Sklar
Journal:  J Biomol Screen       Date:  2009-12-11

10.  Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis.

Authors:  Pierre Morin; Cristina Flors; Michael F Olson
Journal:  Eur J Cell Biol       Date:  2009-06-09       Impact factor: 4.492
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.