PURPOSE: (S,S)-[(18)F]FMeNER-D(2) is a recently developed positron-emission tomography (PET) radioligand for in vivo quantification of the norepinephrine transporter system. The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements. METHODS: PET scans were performed for a total of 6.4 h after the injection of 168.9 +/- 31.5 MBq of (S,S)-[(18)F]FMeNER-D(2) in four healthy male subjects. Volumes of interest were drawn on the coronal images. Estimates of the absorbed dose of radiation were calculated using the OLINDA software. RESULTS: Uptake was largest in lungs, followed by liver, bladder, brain and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lung (21.6%ID at 0.3 h), liver (5.1%ID at 0.3 h), bladder (12.2%ID at 6 h) and brain (2.3%ID at 0.3 h). The largest absorbed dose was found in the urinary bladder wall (0.039 mGy/MBq). The calculated effective dose was 0.017 mSv/MBq. CONCLUSION: Based on the distribution and dose estimates, the estimated radiation burden of (S,S)-[(18)F]FMeNER-D(2) is lower than that of [(18)F]FDG. The radioligand would allow multiple PET examinations in the same research subject per year.
PURPOSE: (S,S)-[(18)F]FMeNER-D(2) is a recently developed positron-emission tomography (PET) radioligand for in vivo quantification of the norepinephrine transporter system. The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements. METHODS: PET scans were performed for a total of 6.4 h after the injection of 168.9 +/- 31.5 MBq of (S,S)-[(18)F]FMeNER-D(2) in four healthy male subjects. Volumes of interest were drawn on the coronal images. Estimates of the absorbed dose of radiation were calculated using the OLINDA software. RESULTS: Uptake was largest in lungs, followed by liver, bladder, brain and other organs. Peak values of the percent injected dose (%ID) at a time after radioligand injection were calculated for the lung (21.6%ID at 0.3 h), liver (5.1%ID at 0.3 h), bladder (12.2%ID at 6 h) and brain (2.3%ID at 0.3 h). The largest absorbed dose was found in the urinary bladder wall (0.039 mGy/MBq). The calculated effective dose was 0.017 mSv/MBq. CONCLUSION: Based on the distribution and dose estimates, the estimated radiation burden of (S,S)-[(18)F]FMeNER-D(2) is lower than that of [(18)F]FDG. The radioligand would allow multiple PET examinations in the same research subject per year.
Authors: T A Deterding; J R Votaw; C K Wang; D Eshima; L Eshima; R Keil; E Malveaux; C D Kilts; M M Goodman; J M Hoffman Journal: J Nucl Med Date: 2001-02 Impact factor: 10.057
Authors: T Spencer; J Biederman; T Wilens; J Prince; M Hatch; J Jones; M Harding; S V Faraone; L Seidman Journal: Am J Psychiatry Date: 1998-05 Impact factor: 18.112
Authors: Nicholas Seneca; Balázs Gulyás; Andrea Varrone; Magnus Schou; Anu Airaksinen; Johannes Tauscher; Francois Vandenhende; William Kielbasa; Lars Farde; Robert B Innis; Christer Halldin Journal: Psychopharmacology (Berl) Date: 2006-08-04 Impact factor: 4.530
Authors: T Suhara; Y Sudo; K Yoshida; Y Okubo; H Fukuda; T Obata; K Yoshikawa; K Suzuki; Y Sasaki Journal: Lancet Date: 1998-01-31 Impact factor: 79.321
Authors: William Robeson; Vijay Dhawan; Abdel Belakhlef; Yilong Ma; Von Pillai; Thomas Chaly; Claude Margouleff; David Bjelke; David Eidelberg Journal: J Nucl Med Date: 2003-06 Impact factor: 10.057
Authors: Shu-fei Lin; Xiaoning Fan; Catherine Weikart Yeckel; David Weinzimmer; Tim Mulnix; Jean-Dominique Gallezot; Richard E Carson; Robert S Sherwin; Yu-Shin Ding Journal: Nucl Med Biol Date: 2012-05-16 Impact factor: 2.408
Authors: Xiaofeng Bao; Shuiyu Lu; Jeih-San Liow; Sami S Zoghbi; Kimberly J Jenko; David T Clark; Robert L Gladding; Robert B Innis; Victor W Pike Journal: J Med Chem Date: 2012-02-16 Impact factor: 7.446
Authors: Akihiro Takano; Balázs Gulyás; Andrea Varrone; Per Karlsson; Nils Sjoholm; Stig Larsson; Cathrine Jonsson; Richard Odh; Richard Sparks; Nabil Al Tawil; Anja Hoffmann; Torsten Zimmermann; Andrea Thiele; Christer Halldin Journal: Eur J Nucl Med Mol Imaging Date: 2011-07-06 Impact factor: 9.236
Authors: Akihiro Takano; Balázs Gulyás; Andrea Varrone; Ralph Paul Maguire; Christer Halldin Journal: Eur J Nucl Med Mol Imaging Date: 2009-03-20 Impact factor: 9.236