Richard Béliveau1, Denis Gingras. 1. Laboratoire de Médecine Moléculaire, Centre de Recherche de l'Hôpital Ste-Justine, 3175 chemin Côte-Ste-Catherine, Montréal, QC. beliveau.richard@uqam.ca
Abstract
OBJECTIVE: To summarize the evidence linking dietary habits to the incidence of several types of cancer with special emphasis on the chemoprotective properties of foods that originate from plants. QUALITY OF EVIDENCE: A large body of epidemiologic, animal, and laboratory literature indicates that as many as 30% of all cancer cases are linked to poor dietary habits. The proportion reaches 70% for cancers of the gastrointestinal tract. MAIN MESSAGE: Studies have consistently linked abundant consumption of plant-based food to a substantial reduction in risk of developing various cancers. Laboratory studies show that this chemopreventive effect is related to the high levels of numerous phytochemicals in this food. These phytochemicals interfere with several cellular processes involved in the progression of cancer and also with inflammatory processes that foster development of cancer. CONCLUSION: Dietary factors play an important role in the high incidence of several types of cancer in Canada. Modification of dietary habits to include daily intake of plant-based food containing anticancer and anti-inflammatory phytochemicals thus represents a promising approach to preventing the development of cancer.
OBJECTIVE: To summarize the evidence linking dietary habits to the incidence of several types of cancer with special emphasis on the chemoprotective properties of foods that originate from plants. QUALITY OF EVIDENCE: A large body of epidemiologic, animal, and laboratory literature indicates that as many as 30% of all cancer cases are linked to poor dietary habits. The proportion reaches 70% for cancers of the gastrointestinal tract. MAIN MESSAGE: Studies have consistently linked abundant consumption of plant-based food to a substantial reduction in risk of developing various cancers. Laboratory studies show that this chemopreventive effect is related to the high levels of numerous phytochemicals in this food. These phytochemicals interfere with several cellular processes involved in the progression of cancer and also with inflammatory processes that foster development of cancer. CONCLUSION: Dietary factors play an important role in the high incidence of several types of cancer in Canada. Modification of dietary habits to include daily intake of plant-based food containing anticancer and anti-inflammatory phytochemicals thus represents a promising approach to preventing the development of cancer.
Authors: G Steinbach; P M Lynch; R K Phillips; M H Wallace; E Hawk; G B Gordon; N Wakabayashi; B Saunders; Y Shen; T Fujimura; L K Su; B Levin; L Godio; S Patterson; M A Rodriguez-Bigas; S L Jester; K L King; M Schumacher; J Abbruzzese; R N DuBois; W N Hittelman; S Zimmerman; J W Sherman; G Kelloff Journal: N Engl J Med Date: 2000-06-29 Impact factor: 91.245
Authors: P Lichtenstein; N V Holm; P K Verkasalo; A Iliadou; J Kaprio; M Koskenvuo; E Pukkala; A Skytthe; K Hemminki Journal: N Engl J Med Date: 2000-07-13 Impact factor: 91.245
Authors: M Jang; L Cai; G O Udeani; K V Slowing; C F Thomas; C W Beecher; H H Fong; N R Farnsworth; A D Kinghorn; R G Mehta; R C Moon; J M Pezzuto Journal: Science Date: 1997-01-10 Impact factor: 47.728
Authors: Eunyoung Cho; Wendy Y Chen; David J Hunter; Meir J Stampfer; Graham A Colditz; Susan E Hankinson; Walter C Willett Journal: Arch Intern Med Date: 2006-11-13
Authors: Cynthia A Thomson; Tracy E Crane; David O Garcia; Betsy C Wertheim; Melanie Hingle; Linda Snetselaar; Mridul Datta; Thomas Rohan; Erin LeBlanc; Rowan T Chlebowski; Lihong Qi Journal: J Acad Nutr Diet Date: 2017-08-17 Impact factor: 4.910
Authors: Katia Lofano; Mariabeatrice Principi; Maria Principia Scavo; Maria Pricci; Enzo Ierardi; Alfredo Di Leo Journal: J Gastrointest Cancer Date: 2013-03
Authors: Chia-Chien Hsieh; Blanca Hernández-Ledesma; Hyun Jin Jeong; Jae Ho Park; Ben O de Lumen Journal: PLoS One Date: 2010-01-26 Impact factor: 3.240