Power estimation of the t test for detecting differential gene expression.

There exist now a number of statistical methods for detecting differential gene expression in experiments with microarray data. In trials under two conditions, a version of the two-sample t statistic is usually used. However, the problem of estimating the power for these tests has so far been insufficiently studied. In this paper, we propose a method to calculate the power of the robust t test for detecting differential gene expression in experiments with twins. We discuss also the results of the implementation of this method to simulated data.