| Literature DB >> 17997280 |
Anvita Kale1, Sadhana Joshi, Nilesh Naphade, Swati Sapkale, M S V K Raju, Anilkumar Pillai, Henry Nasrallah, Sahebarao P Mahadik.
Abstract
Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p=<0.01) whereas higher in CSF (p=<0.01) in male>female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.Entities:
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Year: 2007 PMID： 17997280 DOI： 10.1016/j.schres.2007.09.036
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939