OBJECTIVE: To describe the prevalence, associated anomalies, prenatal diagnosis, and survival of cases of congenital small intestinal atresia (SIA). METHOD: Data were extracted from the Northern Congenital Abnormality Survey (NorCAS) for cases delivered during 1991 to 2001. RESULTS: A total of 99 cases of SIA were notified from 372 717 registered births. Twenty-five (25.8%) SIA cases were associated with a chromosomal anomaly. Of the 72 SIA cases with normal karyotype, 18 (25%) were associated with other structural anomalies. The total prevalence for all SIA cases over the 11 years was 2.66 per 10 000 registered births (95% CI 2.13, 3.18), and the livebirth prevalence was 2.37 per 10 000 livebirths (95% CI 1.88, 2.87). For jejunoileal atresia, the total prevalence increased from 0.54 per 10 000 births during 1991-1995 to 1.11 per 10 000 births during 1996-2001, and livebirth prevalence increased from 0.49 to 1.06 per 10 000 livebirths. The more proximal the lesion the prenatal diagnosis sensitivity was slightly better with 19 (44.2%) cases of duodenal atresia and 3 (42.8%) cases of jejunal atresia diagnosed prenatally by routine ultrasonography. CONCLUSION: This population-based study of SIA has confirmed several previous findings but, by considering subtypes separately, it also suggests a trend towards an increase in the prevalence of jejunoileal atresia (JIA). Copyright (c) 2007 John Wiley & Sons, Ltd.
OBJECTIVE: To describe the prevalence, associated anomalies, prenatal diagnosis, and survival of cases of congenital small intestinal atresia (SIA). METHOD: Data were extracted from the Northern Congenital Abnormality Survey (NorCAS) for cases delivered during 1991 to 2001. RESULTS: A total of 99 cases of SIA were notified from 372 717 registered births. Twenty-five (25.8%) SIA cases were associated with a chromosomal anomaly. Of the 72 SIA cases with normal karyotype, 18 (25%) were associated with other structural anomalies. The total prevalence for all SIA cases over the 11 years was 2.66 per 10 000 registered births (95% CI 2.13, 3.18), and the livebirth prevalence was 2.37 per 10 000 livebirths (95% CI 1.88, 2.87). For jejunoileal atresia, the total prevalence increased from 0.54 per 10 000 births during 1991-1995 to 1.11 per 10 000 births during 1996-2001, and livebirth prevalence increased from 0.49 to 1.06 per 10 000 livebirths. The more proximal the lesion the prenatal diagnosis sensitivity was slightly better with 19 (44.2%) cases of duodenal atresia and 3 (42.8%) cases of jejunal atresia diagnosed prenatally by routine ultrasonography. CONCLUSION: This population-based study of SIA has confirmed several previous findings but, by considering subtypes separately, it also suggests a trend towards an increase in the prevalence of jejunoileal atresia (JIA). Copyright (c) 2007 John Wiley & Sons, Ltd.
Authors: Philip J Lupo; Jennifer L Isenburg; Jason L Salemi; Cara T Mai; Rebecca F Liberman; Mark A Canfield; Glenn Copeland; Sarah Haight; Sanjiv Harpavat; Adrienne T Hoyt; Cynthia A Moore; Wendy N Nembhard; Hoang N Nguyen; Rachel E Rutkowski; Amy Steele; C J Alverson; Erin B Stallings; Russell S Kirby Journal: Birth Defects Res Date: 2017-11-01 Impact factor: 2.344
Authors: Warwick J Teague; Matthew L M Jones; Leanne Hawkey; Ian M Smyth; Angelique Catubig; Sebastian K King; Gulcan Sarila; Ruili Li; John M Hutson Journal: Front Genet Date: 2018-11-09 Impact factor: 4.599