Literature DB >> 1799409

A strongly basic protein of the MAP2 family copolymerizes with tubulin and induces polymerization.

M Nguyen1, H Fasold.   

Abstract

The family of microtubuli-associated proteins of approximately 300 kD molecular weight (MAP2) from porcine brain was fractionated into components of neutral isoelectric point and one polypeptide of strongly basic nature. Both fractions are able to induce the polymerization of purified porcine brain tubulin. In the case of the fractions of an isoelectric point of 7.2, thick and short tubular structures result. Under the influence of the basic protein, extremely long tubules of normal diameter of microtubules are produced. This basic MAP2 copolymerizes with tubulin.

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Year:  1991        PMID： 1799409     DOI： 10.1007/BF01025479

Source DB:  PubMed          Journal:  J Protein Chem        ISSN： 0277-8033


  18 in total

1.  Comparison of the sedimentation properties of microtubule protein oligomers prepared by two different procedures.

Authors:  R B Scheele; G G Borisy
Journal:  Biochem Biophys Res Commun       Date:  1976-05-03       Impact factor: 3.575

2.  Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules.

Authors:  F Gaskin; C R Cantor; M L Shelanski
Journal:  J Mol Biol       Date:  1974-11-15       Impact factor: 5.469

3.  Microtubule assembly in the absence of added nucleotides.

Authors:  M L Shelanski; F Gaskin; C R Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

4.  Enzyme-linked immunoelectrotransfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis.

Authors:  V C Tsang; J M Peralta; A R Simons
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

5.  Effect of ATP on the kinetics of microtubule assembly.

Authors:  J R Zabrecky; R D Cole
Journal:  J Biol Chem       Date:  1982-04-25       Impact factor: 5.157

6.  Strongly basic polypeptides among microtubule associated proteins.

Authors:  M Bärmann; K Mann; H Fasold
Journal:  Biochem Biophys Res Commun       Date:  1982-03-30       Impact factor: 3.575

7.  Microtubule formation in vitro in solutions containing low calcium concentrations.

Authors:  R C Weisenberg
Journal:  Science       Date:  1972-09-22       Impact factor: 47.728

8.  Calmodulin binds to both microtubule-associated protein 2 and tau proteins.

Authors:  Y C Lee; J Wolff
Journal:  J Biol Chem       Date:  1984-01-25       Impact factor: 5.157

9.  Structural homology of microtubule-associated proteins 1 and 2 demonstrated by peptide mapping and immunoreactivity.

Authors:  H Herrmann; R Pytela; J M Dalton; G Wiche
Journal:  J Biol Chem       Date:  1984-01-10       Impact factor: 5.157

10.  Evidence for four classes of microtubules in individual cells.

Authors:  O Behnke; A Forer
Journal:  J Cell Sci       Date:  1967-06       Impact factor: 5.285
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  1 in total

1.  Investigations into the biochemical basis of neuromodulation by 2-phenylethylamine: effect on microtubule protein.

Authors:  M E Knight; J Harris
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996
  1 in total

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