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Literature DB >> 17993570

Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis.

Libera Lo Presti¹, Moira Cockell, Lorenzo Cerutti, Viesturs Simanis, Philippe M Hauser.

Abstract

Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts.

Entities: Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17993570 PMCID： PMC2168235 DOI： 10.1128/EC.00321-07

Source DB: PubMed Journal: Eukaryot Cell ISSN： 1535-9786

19 in total

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12 in total

Review 1. Pneumocystis.

Authors: Francis Gigliotti; Andrew H Limper; Terry Wright
Journal: Cold Spring Harb Perspect Med Date: 2014-11-03 Impact factor: 6.915

2. Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore Complex Biogenesis.

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Journal: Yeast Date: 2011-09-08 Impact factor: 3.239

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Authors: A Luraschi; O H Cissé; M Monod; M Pagni; P M Hauser
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6. Functional differentiation of tbf1 orthologues in fission and budding yeasts.

Authors: Moira M Cockell; Libera Lo Presti; Lorenzo Cerutti; Elena Cano Del Rosario; Philippe M Hauser; Viesturs Simanis
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Authors: A Luraschi; S Richard; P M Hauser
Journal: Antimicrob Agents Chemother Date: 2018-11-26 Impact factor: 5.191

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Authors: Diana Rüthnick; Elmar Schiebel
Journal: Cells Date: 2018-05-10 Impact factor: 6.600