Literature DB >> 17990028

Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital.

Philip C Spinella1, Jeremy G Perkins, Kurt W Grathwohl, Thomas Repine, Alec C Beekley, James Sebesta, Donald Jenkins, Kenneth Azarow, John B Holcomb.   

Abstract

BACKGROUND: United States military doctrine permits the use of fresh whole blood (FWB), donated by U.S. military personnel on site, for casualties with life-threatening injuries at combat support hospitals. U.S. Military Medical Department policy dictates that all patients treated at military facilities during combat (coalition military personnel, foreign nationals, and enemy combatants) are to be treated equally. The objectives of this study were to describe admission vital signs and laboratory values and injury location for patients transfused with FWB, and to determine if FWB was employed equally among all patient personnel categories at a combat support hospital.
METHODS: This retrospective cohort study evaluated admission vital signs and laboratory values, injury location, and personnel category for all patients receiving FWB at a U.S. Army combat support hospital in Baghdad, Iraq, between January and December 2004.
RESULTS: Eighty-seven patients received 545 units of FWB. Upon admission, the average (+/-S.D.) heart rate was 144 bpm (+/-25); systolic blood pressure, 106 mmHg (+/-33); base deficit, 9 (+/-6.5); hemoglobin, 9.0 g/dl (+/-2.6); platelet concentration, 81.9 x 10(3)/mm(3) (+/-81); international normalized ratio (INR), 2.0 (+/-1.1); and temperature 95.7 degrees F (+/-2.6). The percentages of intensive care patients who received FWB by personnel category were as follows: coalition soldiers, 51/592 (8.6%); foreign nationals, 25/347 (7.2%); and enemy combatants, 11/128 (8.5% (p = 0.38). The amount of FWB transfused by personnel category was as follows: coalition soldier, 4 units (1-35); foreign national, 4 units (1-36); and enemy combatant, 4 units (1-11) (p = 0.9).
CONCLUSIONS: Fresh whole blood was used for anemic, acidemic, hypothermic, coagulopathic patients with life-threatening traumatic injuries in hemorrhagic shock, and it was transfused in equal percentages and amounts for coalition soldiers, foreign nationals, and enemy combatants.

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Year:  2007        PMID: 17990028     DOI: 10.1007/s00268-007-9201-5

Source DB:  PubMed          Journal:  World J Surg        ISSN: 0364-2313            Impact factor:   3.352


  38 in total

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Authors:  John R Hess; John B Holcomb; David B Hoyt
Journal:  Transfusion       Date:  2006-05       Impact factor: 3.157

Review 2.  Clinical consequences of red cell storage in the critically ill.

Authors:  Alan Tinmouth; Dean Fergusson; Ian Chin Yee; Paul C Hébert
Journal:  Transfusion       Date:  2006-11       Impact factor: 3.157

3.  Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited.

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4.  Independent contributions of hypothermia and acidosis to coagulopathy in swine.

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Journal:  J Trauma       Date:  2005-05

5.  Combat stress reactions in Iraqi enemy prisoners of war.

Authors:  J M Marcum; D W Cline
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6.  Use of unrefrigerated fresh whole blood in massive transfusion.

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Review 7.  The coagulopathy of trauma versus disseminated intravascular coagulation.

Authors:  John R Hess; Jeffrey H Lawson
Journal:  J Trauma       Date:  2006-06

Review 8.  Are we giving enough coagulation factors during major trauma resuscitation?

Authors:  Anthony M-H Ho; Manoj K Karmakar; Peter W Dion
Journal:  Am J Surg       Date:  2005-09       Impact factor: 2.565

9.  The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital.

Authors:  Matthew A Borgman; Philip C Spinella; Jeremy G Perkins; Kurt W Grathwohl; Thomas Repine; Alec C Beekley; James Sebesta; Donald Jenkins; Charles E Wade; John B Holcomb
Journal:  J Trauma       Date:  2007-10

10.  Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries.

Authors:  W H Bickell; M J Wall; P E Pepe; R R Martin; V F Ginger; M K Allen; K L Mattox
Journal:  N Engl J Med       Date:  1994-10-27       Impact factor: 91.245

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  14 in total

1.  Toward a definition of "fresh" whole blood: an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion.

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Journal:  Transfusion       Date:  2011-01       Impact factor: 3.157

2.  Fixed rate of blood component improves the survival rate of patients in massive transfusion.

Authors:  Wen-Ting Wang; Yong-Hua Zhan; Xing-Bin Hu; Shi-Jie Mu; Qun-Xing An; Zhi-Xin Liu; Xian-Qing Zhang
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3.  Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood.

Authors:  Rachael P Jackman; Marcus O Muench; Heather Inglis; John W Heitman; Susanne Marschner; Raymond P Goodrich; Philip J Norris
Journal:  Transfusion       Date:  2016-11-18       Impact factor: 3.157

4.  Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury.

Authors:  Scott C Brakenridge; Herb A Phelan; Steven S Henley; Richard M Golden; T Michael Kashner; Alexander E Eastman; Jason L Sperry; Brian G Harbrecht; Ernest E Moore; Joseph Cuschieri; Ronald V Maier; Joseph P Minei
Journal:  J Trauma       Date:  2011-08

5.  Massive Bleeding and Massive Transfusion.

Authors:  Andreas Meißner; Peter Schlenke
Journal:  Transfus Med Hemother       Date:  2012-03-12       Impact factor: 3.747

6.  The Evolution of Blood Product Use in Trauma Resuscitation: Change Has Come.

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7.  Effects of platelet-sparing leukocyte reduction and agitation methods on in vitro measures of hemostatic function in cold-stored whole blood.

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8.  The use of whole blood in traumatic bleeding: a systematic review.

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9.  Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries.

Authors:  Philip C Spinella; Jeremy G Perkins; Kurt W Grathwohl; Alec C Beekley; John B Holcomb
Journal:  J Trauma       Date:  2009-04

Review 10.  Optimal use of blood in trauma patients.

Authors:  John B Holcomb; Philip C Spinella
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