Literature DB >> 17989340

Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients.

Mouna Stayoussef1, Fayza A Al-Jenaidi, Abduljabbar Al-Abbasi, Khadija Al-Ola, Haya Khayyat, Touhami Mahjoub, Wassim Y Almawi.   

Abstract

Tumor necrosis factor alpha (TNF-alpha) -308 G/A and lymphotoxin alpha (LTalpha) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTalpha +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-alpha/LTalpha alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-alpha/LTalpha T1DM-susceptible (-308G/+249G) and protective (-308G/+249A) haplotypes were identified.

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Year:  2007        PMID： 17989340      PMCID： PMC2238059          DOI： 10.1128/CVI.00410-07

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  19 in total

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4.  Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes.

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  2 in total

1.  Associations between TNF gene polymorphisms (-308 A/G, -238 A/G, -1031 C/T and -857 T/C) and genetic susceptibility to T1D: a meta-analysis.

Authors:  Peng-Fei Wen; Xiao-Song Wang; Min Zhang; Han Cen; Hai-Feng Pan; Qian-Ling Ye; Chen Mao; Dong-Qing Ye
Journal:  Endocrine       Date:  2014-02-11       Impact factor: 3.633

2.  Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.

Authors:  Vesna Boraska; Eleftheria Zeggini; Christopher J Groves; Nigel W Rayner; Veselin Skrabić; Mahamadou Diakite; Kirk A Rockett; Dominic Kwiatkowski; Mark I McCarthy; Tatijana Zemunik
Journal:  Hum Immunol       Date:  2009-01-22       Impact factor: 2.850
  2 in total

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