Literature DB >> 12568117

TNF-alpha and -beta gene polymorphisms in multiple sclerosis: a highly significant role for determinants in the first intron of the TNF-beta gene.

Jose Americo M Fernandes Filho1, Christian A Vedeler, Kjell-Morten Myhr, Harald Nyland, Janardan P Pandey.   

Abstract

Tumor necrosis factor (TNF)-alpha and TNF-beta are proinflammatory cytokines that have been implicated in the pathogenesis of several autoimmune diseases. The aim of this investigation was to determine whether a determinant in the first intron of the TNF-beta gene (TNF-beta(+252)) and two promoter-region polymorphisms of the TNF-alpha gene (TNF-alpha(-308) and TNF-alpha(-238)) affect susceptibility to multiple sclerosis (MS). DNA samples from 133 Caucasian MS patients and 148 healthy controls from Norway were genotyped for several polymorphic determinants, using polymerase chain reaction-based restriction fragment length polymorphisms (PCR-RFLP) methods. TNF-beta(+252) genotypes were significantly associated with MS: The frequency of TNF-beta 2,2 was increased (p = 0.00009) while the frequency of TNF-beta 1,2 was decreased (p = 0.0012) in MS patients as compared to controls. TNF-alpha genotypes were not associated with MS. These results suggest that the TNF-beta gene plays a significant role in the etiopathogenesis of MS.

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Year:  2002        PMID： 12568117     DOI： 10.1080/0891693021000021549

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  7 in total

1.  Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls.

Authors:  Andrea T White; Alan R Light; Ronald W Hughen; Timothy A Vanhaitsma; Kathleen C Light
Journal:  Psychosom Med       Date:  2011-12-30       Impact factor: 4.312

2.  Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions.

Authors:  Melanie D Napier; Charles Poole; Glen A Satten; Allison Ashley-Koch; Ruth Ann Marrie; Dhelia M Williamson
Journal:  Arch Environ Occup Health       Date:  2014-08-19       Impact factor: 1.663

3.  The epidemiology of Kawasaki disease in an urban hospital: does African American race protect against coronary artery aneurysms?

Authors:  A R Porcalla; C A Sable; K M Patel; G R Martin; N Singh
Journal:  Pediatr Cardiol       Date:  2005 Nov-Dec       Impact factor: 1.655

4.  Tumor necrosis factor alpha gene -376 polymorphism and susceptibility to multiple sclerosis: an Egyptian study.

Authors:  Mona Abd el Fattah Nada; Dalia Ahmed Labib
Journal:  J Neuroimmune Pharmacol       Date:  2010-05-25       Impact factor: 4.147

5.  Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection.

Authors:  Christian R Engwerda; Manabu Ato; Simona Stäger; Clare E Alexander; Amanda C Stanley; Paul M Kaye
Journal:  Am J Pathol       Date:  2004-12       Impact factor: 4.307

6.  Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients.

Authors:  Mouna Stayoussef; Fayza A Al-Jenaidi; Abduljabbar Al-Abbasi; Khadija Al-Ola; Haya Khayyat; Touhami Mahjoub; Wassim Y Almawi
Journal:  Clin Vaccine Immunol       Date:  2007-11-07

Review 7.  Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis.

Authors:  Hamidreza Tolide-Ie; Hamid Reza Tabatabaee; Eskandar Kamali-Sarvestani
Journal:  Iran J Med Sci       Date:  2014-01
  7 in total

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