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Literature DB >> 17988934

Sophistication of foldamer form and function in vitro and in vivo.

Arjel D Bautista¹, Cody J Craig, Elizabeth A Harker, Alanna Schepartz.

Abstract

Advances in the foldamer field in recent years are as diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the realm of tertiary and quaternary structure. This review will provide recent examples of progress in the foldamer field, highlighting the significance of this class of compounds and the advances that have been made towards exploiting their full potential.

Mesh：

Substances：
Peptides
Polymers

Year: 2007 PMID： 17988934 PMCID： PMC2752848 DOI： 10.1016/j.cbpa.2007.09.009

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

63 in total

Review 1. DNA recognition by Cys2His2 zinc finger proteins.

Authors: S A Wolfe; L Nekludova; C O Pabo
Journal: Annu Rev Biophys Biomol Struct Date: 2000

2. Toward beta-peptide tertiary structure: self-association of an amphiphilic 14-helix in aqueous solution.

Authors: T L Raguse; J R Lai; P R LePlae; S H Gellman
Journal: Org Lett Date: 2001-11-29 Impact factor: 6.005

3. Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.

Authors: B P Orner; J T Ernst; A D Hamilton
Journal: J Am Chem Soc Date: 2001-06-06 Impact factor: 15.419

4. Biphenyls as potential mimetics of protein alpha-helix.

Authors: Edgar Jacoby
Journal: Bioorg Med Chem Lett Date: 2002-03-25 Impact factor: 2.823

5. The outstanding biological stability of beta- and gamma-peptides toward proteolytic enzymes: an in vitro investigation with fifteen peptidases.

Authors: J Frackenpohl; P I Arvidsson; J V Schreiber; D Seebach
Journal: Chembiochem Date: 2001-06-01 Impact factor: 3.164

6. Translocation of a beta-peptide across cell membranes.

Authors: Naoki Umezawa; Michael A Gelman; Marcia C Haigis; Ronald T Raines; Samuel H Gellman
Journal: J Am Chem Soc Date: 2002-01-23 Impact factor: 15.419

7. Peptide hybrids containing alpha - and beta-amino acids: structure of a decapeptide beta-hairpin with two facing beta-phenylalanine residues.

Authors: I L Karle; H N Gopi; P Balaram
Journal: Proc Natl Acad Sci U S A Date: 2001-03-20 Impact factor: 11.205

8. De novo design of biomimetic antimicrobial polymers.

Authors: Gregory N Tew; Dahui Liu; Bin Chen; Robert J Doerksen; Justin Kaplan; Patrick J Carroll; Michael L Klein; William F DeGrado
Journal: Proc Natl Acad Sci U S A Date: 2002-04-16 Impact factor: 11.205

9. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.

Authors: P A Wender; D J Mitchell; K Pattabiraman; E T Pelkey; L Steinman; J B Rothbard
Journal: Proc Natl Acad Sci U S A Date: 2000-11-21 Impact factor: 11.205

10. Activation of gene expression by small molecule transcription factors.

Authors: A K Mapp; A Z Ansari; M Ptashne; P B Dervan
Journal: Proc Natl Acad Sci U S A Date: 2000-04-11 Impact factor: 11.205

23 in total

Review 1. High-definition self-assemblies driven by the hydrophobic effect: synthesis and properties of a supramolecular nanocapsule.

Authors: Simin Liu; Bruce C Gibb
Journal: Chem Commun (Camb) Date: 2008-06-06 Impact factor: 6.222

10. Synthesis and structural characterization of sialic acid-glutamic acid hybrid foldamers as conformational surrogates of alpha-2,8-linked polysialic acid.

Authors: Jonel P Saludes; James B Ames; Jacquelyn Gervay-Hague
Journal: J Am Chem Soc Date: 2009-04-22 Impact factor: 15.419

Sophistication of foldamer form and function in vitro and in vivo.

Review 1. DNA recognition by Cys2His2 zinc finger proteins.

2. Toward beta-peptide tertiary structure: self-association of an amphiphilic 14-helix in aqueous solution.

3. Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.

4. Biphenyls as potential mimetics of protein alpha-helix.

5. The outstanding biological stability of beta- and gamma-peptides toward proteolytic enzymes: an in vitro investigation with fifteen peptidases.

6. Translocation of a beta-peptide across cell membranes.

7. Peptide hybrids containing alpha - and beta-amino acids: structure of a decapeptide beta-hairpin with two facing beta-phenylalanine residues.

8. De novo design of biomimetic antimicrobial polymers.

9. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.

10. Activation of gene expression by small molecule transcription factors.

Review 1. High-definition self-assemblies driven by the hydrophobic effect: synthesis and properties of a supramolecular nanocapsule.

2. Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure.

Review 3. Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.

4. Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation.

5. Infrared signature and folding dynamics of a helical beta-peptide.

Review 6. Folding and function in α/β-peptides: targets and therapeutic applications.

7. Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation.

8. Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells.

9. Tetrameric beta(3)-peptide bundles.

10. Synthesis and structural characterization of sialic acid-glutamic acid hybrid foldamers as conformational surrogates of alpha-2,8-linked polysialic acid.