OBJECTIVE: In human genetic studies an effect of the apolipoprotein E gene (APOE) polymorphism on the risk, course and prognosis in chronic and acute nervous system disorders was established. We aimed to evaluate whether the APOE genotype is related to acute neurological impairments due to ischemic stroke (IS), and to outcomes (up to 1 year) indicated by severe functional disability, dependence in daily living or death. MATERIALS AND METHODS: A total of 657 patients (326 men, 331 women), divided into the three groups: E2 (APOEepsilon2/epsilon3 subjects), E3 (APOEepsilon3/epsilon3 subjects), and E4 (APOEepsilon3/epsilon4 and epsilon4/epsilon4 subjects), were analyzed. RESULTS: There was no association between the APOE genotype and baseline clinical characteristics, severity of neurological impairments during acute stroke, and 1-year outcome, when analyzing whole patient population. APOE gene interacted with gender in predicting severity of acute neurological deficit and post-stroke mortality within the period up to 1 year after the IS. Gender-stratified analysis indicated the E4 genotype as a significant independent positive predictor of death within 1 year after stroke incidence in men patients. CONCLUSION: Ischemic stroke severity and outcome may be affected by complex interactions between gender and genetic factors that warrant further exploration.
OBJECTIVE: In human genetic studies an effect of the apolipoprotein E gene (APOE) polymorphism on the risk, course and prognosis in chronic and acute nervous system disorders was established. We aimed to evaluate whether the APOE genotype is related to acute neurological impairments due to ischemic stroke (IS), and to outcomes (up to 1 year) indicated by severe functional disability, dependence in daily living or death. MATERIALS AND METHODS: A total of 657 patients (326 men, 331 women), divided into the three groups: E2 (APOEepsilon2/epsilon3 subjects), E3 (APOEepsilon3/epsilon3 subjects), and E4 (APOEepsilon3/epsilon4 and epsilon4/epsilon4 subjects), were analyzed. RESULTS: There was no association between the APOE genotype and baseline clinical characteristics, severity of neurological impairments during acute stroke, and 1-year outcome, when analyzing whole patient population. APOE gene interacted with gender in predicting severity of acute neurological deficit and post-stroke mortality within the period up to 1 year after the IS. Gender-stratified analysis indicated the E4 genotype as a significant independent positive predictor of death within 1 year after stroke incidence in menpatients. CONCLUSION:Ischemic stroke severity and outcome may be affected by complex interactions between gender and genetic factors that warrant further exploration.
Authors: Michelle M Mielke; Jeannie-Marie Leoutsakos; JoAnn T Tschanz; Robert C Green; Yorghos Tripodis; Chris D Corcoran; Maria C Norton; Constantine G Lyketsos Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472
Authors: R J Caselli; A C Dueck; D E C Locke; M N Sabbagh; G L Ahern; S Z Rapcsak; L C Baxter; R Yaari; B K Woodruff; C Hoffman-Snyder; R Rademakers; S Findley; E M Reiman Journal: Neurology Date: 2011-02-16 Impact factor: 9.910
Authors: Leon M Tai; Riya Thomas; Felecia M Marottoli; Kevin P Koster; Takahisa Kanekiyo; Alan W J Morris; Guojun Bu Journal: Acta Neuropathol Date: 2016-02-16 Impact factor: 17.088
Authors: Beilei Lei; Brian Mace; Steven T Bellows; Patrick M Sullivan; Michael P Vitek; Daniel T Laskowitz; Michael L James Journal: Transl Stroke Res Date: 2012-03 Impact factor: 6.829
Authors: Christine T Shiner; Kerrie D Pierce; Angelica G Thompson-Butel; Terry Trinh; Peter R Schofield; Penelope A McNulty Journal: Front Neurol Date: 2016-05-17 Impact factor: 4.003
Authors: Cecilia Lagging; Erik Lorentzen; Tara M Stanne; Annie Pedersen; Martin Söderholm; John W Cole; Katarina Jood; Robin Lemmens; Chia-Ling Phuah; Natalia S Rost; Vincent Thijs; Daniel Woo; Jane M Maguire; Arne Lindgren; Christina Jern Journal: Neurology Date: 2019-10-16 Impact factor: 9.910