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Literature DB >> 17985003

Nonviral vector gene modification of stem cells for myocardial repair.

Husnain K Haider¹, Ibrahim Elmadbouh, Michel Jean-Baptiste, Muhammad Ashraf.

Abstract

Therapeutic angiogenesis and myogenesis restore perfusion of ischemic myocardium and improve left ventricular contractility. These therapeutic modalities must be considered as complementary rather than competing to exploit their advantages for optimal beneficial effects. The resistant nature of cardiomyocytes to gene transfection can be overcome by ex vivo delivery of therapeutic genes to the heart using genetically modified stem cells. This review article gives an overview of different vectors and delivery systems in general used for therapeutic gene delivery to the heart and provides a critical appreciation of the ex vivo gene delivery approach using genetically modified stem cells to achieve angiomyogenesis for the treatment of infarcted heart.

Entities: Disease

Mesh：

Year: 2008 PMID： 17985003 PMCID： PMC2055423 DOI： 10.2119/2007-00092.Haider

Source DB: PubMed Journal: Mol Med ISSN： 1076-1551 Impact factor: 6.354

76 in total

1. Vascular endothelial growth factor transgene expression in cell-transplanted hearts.

Authors: Terrence M Yau; Guangming Li; Richard D Weisel; Adili Reheman; Zhi-Qiang Jia; Donald A G Mickle; Ren-Ke Li
Journal: J Thorac Cardiovasc Surg Date: 2004-04 Impact factor: 5.209

2. Calcium ions as efficient cofactor of polycation-mediated gene transfer.

Authors: A Haberland; T Knaus; S V Zaitsev; R Stahn; A R Mistry; C Coutelle; H Haller; M Böttger
Journal: Biochim Biophys Acta Date: 1999-04-14

3. Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.

Authors: Lap Thi Nguyen; Kazutaka Atobe; Jose Mario Barichello; Tatsuhiro Ishida; Hiroshi Kiwada
Journal: Biol Pharm Bull Date: 2007-04 Impact factor: 2.233

4. Characterization of the interplay between the main factors contributing to lipoplex-mediated transfection in cell cultures.

Authors: Julia Boktov; Danielle Hirsch-Lerner; Yechezkel Barenholz
Journal: J Gene Med Date: 2007-10 Impact factor: 4.565

5. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease.

Authors: T K Rosengart; L Y Lee; S R Patel; T A Sanborn; M Parikh; G W Bergman; R Hachamovitch; M Szulc; P D Kligfield; P M Okin; R T Hahn; R B Devereux; M R Post; N R Hackett; T Foster; T M Grasso; M L Lesser; O W Isom; R G Crystal
Journal: Circulation Date: 1999-08-03 Impact factor: 29.690

6. Gene delivery with low molecular weight linear polyethylenimines.

Authors: Miriam Breunig; Uta Lungwitz; Renate Liebl; Claudia Fontanari; Juergen Klar; Armin Kurtz; Torsten Blunk; Achim Goepferich
Journal: J Gene Med Date: 2005-10 Impact factor: 4.565

7. Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair.

Authors: Shujia Jiang; Husnain Kh Haider; Niagara M Idris; Asmat Salim; Muhammad Ashraf
Journal: Circ Res Date: 2006-09-07 Impact factor: 17.367

8. Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts.

Authors: K Suzuki; B Murtuza; R T Smolenski; I A Sammut; N Suzuki; Y Kaneda; M H Yacoub
Journal: Circulation Date: 2001-09-18 Impact factor: 29.690

9. Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair.

Authors: Yigang Wang; Husnain K Haider; Nauman Ahmad; Meifeng Xu; Ruowen Ge; Muhammad Ashraf
Journal: J Mol Cell Cardiol Date: 2006-05 Impact factor: 5.000

10. Tadalafil, a long acting phosphodiesterase inhibitor, promotes bone marrow stem cell survival and their homing into ischemic myocardium for cardiac repair.

Authors: Ibrahim Elmadbouh; Muhammad Ashraf
Journal: Physiol Rep Date: 2017-11

10 in total

Nonviral vector gene modification of stem cells for myocardial repair.

1. Vascular endothelial growth factor transgene expression in cell-transplanted hearts.

2. Calcium ions as efficient cofactor of polycation-mediated gene transfer.

3. Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.

4. Characterization of the interplay between the main factors contributing to lipoplex-mediated transfection in cell cultures.

5. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease.

6. Gene delivery with low molecular weight linear polyethylenimines.

7. Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair.

8. Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts.

9. Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair.

10. Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD.

Review 1. Angiomyogenesis for myocardial repair.

Review 2. Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies.

Review 3. Stem cell paracrine actions and tissue regeneration.

Review 4. Recent progress on tissue-resident adult stem cell biology and their therapeutic implications.

5. Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation.

Review 6. Functional polymers of gene delivery for treatment of myocardial infarct.

Review 7. Assessment and optimization of cell engraftment after transplantation into the heart.

8. Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase.

Review 9. Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology.

10. Tadalafil, a long acting phosphodiesterase inhibitor, promotes bone marrow stem cell survival and their homing into ischemic myocardium for cardiac repair.