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Literature DB >> 17983676

Epigenetic stability of embryonic stem cells and developmental potential.

Abstract

Recent studies highlight the tremendous potential of human embryonic stem (ES) cells and their derivatives as therapeutic tools for degenerative diseases. However, derivation and culture of ES cells can induce epigenetic alterations, which can have long lasting effects on gene expression and phenotype. Research on human and mouse stem cells indicates that developmental, cancer-related genes, and genes regulated by genomic imprinting are particularly susceptible to changes in DNA methylation. Together with the occurrence of genetic alterations, epigenetic instability needs to be monitored when considering human stem cells for therapeutic and technological purposes. Here, we discuss the maintenance of epigenetic information in cultured stem cells and embryos and how this influences their developmental potential.

Entities: Disease Species

Mesh：

Year: 2007 PMID： 17983676 DOI： 10.1016/j.tibtech.2007.09.003

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

Keyword Cloud
Cited

17 in total

Review 1. Child health, developmental plasticity, and epigenetic programming.

Authors: Z Hochberg; R Feil; M Constancia; M Fraga; C Junien; J-C Carel; P Boileau; Y Le Bouc; C L Deal; K Lillycrop; R Scharfmann; A Sheppard; M Skinner; M Szyf; R A Waterland; D J Waxman; E Whitelaw; K Ong; K Albertsson-Wikland
Journal: Endocr Rev Date: 2010-10-22 Impact factor: 19.871

2. Developing safe therapies from human pluripotent stem cells.

Authors: Melissa K Carpenter; Joyce Frey-Vasconcells; Mahendra S Rao
Journal: Nat Biotechnol Date: 2009-07 Impact factor: 54.908

3. Effects of long-term culture on human embryonic stem cell aging.

Authors: Xiaoyan Xie; Asimina Hiona; Andrew Stephen Lee; Feng Cao; Mei Huang; Zongjin Li; Athena Cherry; Xuetao Pei; Joseph C Wu
Journal: Stem Cells Dev Date: 2010-09-09 Impact factor: 3.272

4. Igf2-H19, an Imprinted Tandem Yin-Yanggene and its Emerging Role in Development, Proliferation of Pluripotent Stem Cells, Senescence and Cancerogenesis.

Authors: Mariusz Z Ratajczak
Journal: J Stem Cell Res Ther Date: 2012-11

5. An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias.

Authors: Paulina A Latos; Stefan H Stricker; Laura Steenpass; Florian M Pauler; Ru Huang; Basak H Senergin; Kakkad Regha; Martha V Koerner; Katarzyna E Warczok; Christine Unger; Denise P Barlow
Journal: Development Date: 2009-02 Impact factor: 6.868

Epigenetic stability of embryonic stem cells and developmental potential.

Review 1. Child health, developmental plasticity, and epigenetic programming.

2. Developing safe therapies from human pluripotent stem cells.

3. Effects of long-term culture on human embryonic stem cell aging.

4. Igf2-H19, an Imprinted Tandem Yin-Yanggene and its Emerging Role in Development, Proliferation of Pluripotent Stem Cells, Senescence and Cancerogenesis.

5. An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias.

6. Epigenetics and cancer, 2nd IARC meeting, Lyon, France, 6 and 7 December 2007.

7. The ghost in our genes: legal and ethical implications of epigenetics.

Review 8. Parthenogenesis as an approach to pluripotency: advantages and limitations involved.

9. Transcriptional differences between rhesus embryonic stem cells generated from in vitro and in vivo derived embryos.

10. Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation.