Literature DB >> 1798287

Role of oxygen radicals in tourniquet-related ischemia-reperfusion injury of human patients.

H P Friedl1, G O Till, O Trentz, P A Ward.   

Abstract

In the current study we evaluated effluent blood from extremities of human patients undergoing reconstructive surgical treatment which is routinely accompanied by upper extremity exsanguination and application of a tourniquet. Following tourniquet release (reperfusion), there were immediate increases in the plasma levels of xanthine oxidase activity, uric acid, and histamine. Xanthine dehydrogenase activity was not detectable. Plasma also contained products consistent with the formation of oxygen-derived free radicals, namely hemoglobin and fluorescent compounds. Our data indicate in humans that ischemia-reperfusion events are associated with the appearance of xanthine oxidase activity and its products in the plasma effluent.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1798287     DOI： 10.1007/BF01645168

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  20 in total

1.  The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O).

Authors:  W R Waud; K V Rajagopalan
Journal:  Arch Biochem Biophys       Date:  1976-02       Impact factor: 4.013

2.  Different ATP-catabolism in reperfused adult and newborn rat hearts.

Authors:  P W Achterberg; A S Nieukoop; B Schoutsen; J W de Jong
Journal:  Am J Physiol       Date:  1988-06

3.  Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts.

Authors:  L J Eddy; J R Stewart; H P Jones; T D Engerson; J M McCord; J M Downey
Journal:  Am J Physiol       Date:  1987-09

4.  Thermal injury, intravascular hemolysis, and toxic oxygen products.

Authors:  J R Hatherill; G O Till; L H Bruner; P A Ward
Journal:  J Clin Invest       Date:  1986-09       Impact factor: 14.808

5.  Fluorescent products from reaction of peroxidizing polyunsaturated fatty acids with phosphatidyl ethanolamine and phenylalanine.

Authors:  C J Dillard; A L Tappel
Journal:  Lipids       Date:  1973-04       Impact factor: 1.880

6.  Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

Authors:  J C Fantone; P A Ward
Journal:  Am J Pathol       Date:  1982-06       Impact factor: 4.307

7.  Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

Authors:  W F Petrone; D K English; K Wong; J M McCord
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

8.  Xanthine oxidase and neutrophil infiltration in intestinal ischemia.

Authors:  M B Grisham; L A Hernandez; D N Granger
Journal:  Am J Physiol       Date:  1986-10

Review 9.  Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury.

Authors:  D N Granger
Journal:  Am J Physiol       Date:  1988-12

10.  Systemic complement activation, lung injury, and products of lipid peroxidation.

Authors:  P A Ward; G O Till; J R Hatherill; T M Annesley; R G Kunkel
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808
View more
  9 in total

Review 1.  Hyperuricemia and Hypertension: Links and Risks.

Authors:  Douglas J Stewart; Valerie Langlois; Damien Noone
Journal:  Integr Blood Press Control       Date:  2019-12-24

2.  Role of leucocytes in free radical production during myocardial revascularisation.

Authors:  E De Vecchi; R Paroni; M G Pala; G Di Credico; V Agape; C Gobbi; P A Bonini; G Paolini; A Grossi
Journal:  Heart       Date:  1997-05       Impact factor: 5.994

Review 3.  Uric acid and hypertension: cause or effect?

Authors:  Marilda Mazzali; Mehmet Kanbay; Mark S Segal; Mohamed Shafiu; Diana Jalal; Daniel I Feig; Richard J Johnson
Journal:  Curr Rheumatol Rep       Date:  2010-04       Impact factor: 4.592

Review 4.  Controlling Reperfusion Injury With Controlled Reperfusion: Historical Perspectives and New Paradigms.

Authors:  Demetria M Fischesser; Bin Bo; Rachel P Benton; Haili Su; Newsha Jahanpanah; Kevin J Haworth
Journal:  J Cardiovasc Pharmacol Ther       Date:  2021-09-17       Impact factor: 2.457

5.  Hepatoxicity of ricin, saporin or a saporin immunotoxin: xanthine oxidase activity in rat liver and blood serum.

Authors:  M G Battelli; L Buonamici; L Polito; A Bolognesi; F Stirpe
Journal:  Virchows Arch       Date:  1996-02       Impact factor: 4.064

6.  Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?

Authors:  Sergey I Zharikov; Erik R Swenson; Miguel Lanaspa; Edward R Block; Jawaharlal M Patel; Richard J Johnson
Journal:  Med Hypotheses       Date:  2010-01-12       Impact factor: 1.538

7.  Comparison of inflammatory markers in non-dipper hypertension vs. dipper hypertension and in normotensive individuals: uric acid, C-reactive protein and red blood cell distribution width readings.

Authors:  Aydin Rodi Tosu; Serafettin Demir; Murat Selcuk; Yuksel Kaya; Aytac Akyol; Mahmut Ozdemir; Erhan Tenekecioglu
Journal:  Postepy Kardiol Interwencyjnej       Date:  2014-06-26       Impact factor: 1.426

Review 8.  Lung injury and oxidoreductases.

Authors:  J R Hoidal; P Xu; T Huecksteadt; K A Sanders; K Pfeffer; A B Sturrock
Journal:  Environ Health Perspect       Date:  1998-10       Impact factor: 9.031

9.  Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study.

Authors:  Jing-Hong Liu; Qing-Hua Ma; Yong Xu; Xing Chen; Chen-Wei Pan
Journal:  Diabetes Metab Syndr Obes       Date:  2020-11-06       Impact factor: 3.168
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.