Literature DB >> 17981628

The biological role of HGF-MET axis in tumor growth and development of metastasis.

Ewa Lesko1, Marcin Majka.   

Abstract

Hepatocyte growth factor (HGF) and its receptor MET play an important role in cancer growth and metastasis. Activation of MET elicit multiple cellular responses regulating cell survival, morphogenesis, adhesion, migration, breakdown of extracellular matrix (ECM) and angiogenesis. Numerous disorders related to deregulation of HGF-MET axis have been reported. Thus, new therapeutic agents targeting HGF-MET signaling have been sought. Here, we will present data describing the role of HGF-MET axis in growth and metastasis of tumor cells together with the recent approaches to block this axis.

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Year:  2008        PMID： 17981628     DOI： 10.2741/2760

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  46 in total

1.  Lentivirus-mediated RNA silencing of c-Met markedly suppresses peritoneal dissemination of gastric cancer in vitro and in vivo.

Authors:  Xiao-lei Wang; Xi-mei Chen; Jian-ping Fang; Chang-qin Yang
Journal:  Acta Pharmacol Sin       Date:  2012-03-12       Impact factor: 6.150

2.  Comment on "Effect of transferred NK4 gene on proliferation, migration, invasion, and apoptosis of human prostate cancer DU145 cells" by Dan Yue et al. in Asian Journal of Andrology.

Authors:  Shahriar Koochekpour
Journal:  Asian J Androl       Date:  2010-04-19       Impact factor: 3.285

Review 3.  Histochemistry and cell biology: the annual review 2010.

Authors:  Stefan Hübner; Athina Efthymiadis
Journal:  Histochem Cell Biol       Date:  2011-01-29       Impact factor: 4.304

4.  Beta-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription.

Authors:  Fei-Yan Pan; Sheng-Zhou Zhang; Na Xu; Fan-Li Meng; Hong-Xia Zhang; Bin Xue; Xiao Han; Chao-Jun Li
Journal:  Histochem Cell Biol       Date:  2010-07-31       Impact factor: 4.304

5.  Angiogenesis and multiple myeloma.

Authors:  Nicola Giuliani; Paola Storti; Marina Bolzoni; Benedetta Dalla Palma; Sabrina Bonomini
Journal:  Cancer Microenviron       Date:  2011-07-07

6.  Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells.

Authors:  Kang Ho Kim; Ho Jun Seol; Eun Hee Kim; Jinguen Rheey; Hyun Jin Jin; Yeri Lee; Kyeung Min Joo; Jeongwu Lee; Do-Hyun Nam
Journal:  Neuro Oncol       Date:  2012-12-20       Impact factor: 12.300

7.  Receptor-type Protein tyrosine phosphatase β regulates met phosphorylation and function in head and neck squamous cell carcinoma.

Authors:  Yiru Xu; Jin Zhou; Thomas E Carey; Jonathan B McHugh; John J Voorhees; Gary J Fisher
Journal:  Neoplasia       Date:  2012-11       Impact factor: 5.715

8.  Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF.

Authors:  Anna A Birukova; Ivan Cokic; Nurgul Moldobaeva; Konstantin G Birukov
Journal:  Am J Respir Cell Mol Biol       Date:  2008-07-29       Impact factor: 6.914

9.  Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells.

Authors:  Md Ruhul Abid; Robert J Nadeau; Katherine C Spokes; Takashi Minami; Dan Li; Shou-Ching Shih; William C Aird
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-09-11       Impact factor: 8.311

10.  Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.

Authors:  Silvia Giampieri; Cerys Manning; Steven Hooper; Louise Jones; Caroline S Hill; Erik Sahai
Journal:  Nat Cell Biol       Date:  2009-10-18       Impact factor: 28.824
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