OBJECTIVE: To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome. DESIGN: Case report. SETTING: Private IVF clinics and a university hospital. PATIENT(S): A 32-year-old woman and a 33-year-old man. INTERVENTION(S): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection. MAIN OUTCOME MEASURE(S): Assessment of fertilization and chromosomal analysis of newborn child. RESULT(S): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy. CONCLUSION(S): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes.
OBJECTIVE: To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome. DESIGN: Case report. SETTING: Private IVF clinics and a university hospital. PATIENT(S): A 32-year-old woman and a 33-year-old man. INTERVENTION(S): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection. MAIN OUTCOME MEASURE(S): Assessment of fertilization and chromosomal analysis of newborn child. RESULT(S): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy. CONCLUSION(S): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes.