Literature DB >> 17980588

Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700.

Sonali Rudra1, Ajay Yadav, A V S Raja Rao, A S S V Srinivas, Manisha Pandya, Pragya Bhateja, Tarun Mathur, Sunita Malhotra, Ashok Rattan, Mohammed Salman, Anita Mehta, Ian A Cliffe, Biswajit Das.   

Abstract

Several potent oxazolidinone antibacterial agents were obtained by systematic modification of the linker between the five-membered heterocycle and the piperazinyl ring of RBx 7644 (Ranbezolid, 1) and its thienyl analogue 2, leading to the identification of an expanded spectrum compound RBx 8700 (6b).

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Year:  2007        PMID: 17980588     DOI: 10.1016/j.bmcl.2007.10.061

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  2-Iodo-5-nitro-thio-phene.

Authors:  Xing Yan Xu; Gang Huang; Xiang Chao Zeng; Fang Hu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-22

Review 2.  Current updates on oxazolidinone and its significance.

Authors:  Neha Pandit; Rajeev K Singla; Birendra Shrivastava
Journal:  Int J Med Chem       Date:  2012-02-26
  2 in total

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