Literature DB >> 17980507

Is the use of a surrogate urethra an option in prostate high-dose-rate brachytherapy?

Josef Nilsson1, Karl Mikael Kälkner, Lars Berg, Seymour Levitt, Carina Holmberg, Sten Nilsson, Marie Lundell.   

Abstract

PURPOSE: To investigate the accuracy and the dosimetric consequences of substituting a surrogate urethra assumed to be at the geometric center of the prostate, in place of the true urethra when using high-dose-rate (HDR) brachytherapy for the treatment of prostate cancer. METHODS AND MATERIALS: One hundred prostate cancer patients treated with HDR brachytherapy constituted the study group. A pre-plan was made with the urethra visualized. The true urethra was defined, and a surrogate urethra was placed at the geometric center of the prostate. The distance between the two urethras was measured. The deviation was evaluated at the base, middle, and apex. To evaluate the dosimetric consequences for the true urethra when using a surrogate urethra, two different dose plans were made: one based on the true urethra and one based on the surrogate urethra. The dose-volume histograms for the true urethra were analyzed.
RESULTS: The deviation between the true urethra and the surrogate urethra was greatest at the base of the prostate. A statistically significant difference was seen between the dosimetric parameters for the true and the surrogate urethra when the dose plan was made using the surrogate urethra. In this situation the dose to the true urethra was increased above our defined maximum tolerance limit.
CONCLUSIONS: When using dose plans made according to a surrogate urethra the dose to the true urethra might be too high to be acceptable. If the true urethra is not visualized, severe damage could easily develop in a significant number of patients.

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Year:  2007        PMID: 17980507     DOI: 10.1016/j.ijrobp.2007.09.025

Source DB:  PubMed          Journal:  Int J Radiat Oncol Biol Phys        ISSN: 0360-3016            Impact factor:   7.038


  2 in total

1.  A comparison of HDR brachytherapy and IMRT techniques for dose escalation in prostate cancer: a radiobiological modeling study.

Authors:  M Fatyga; J F Williamson; N Dogan; D Todor; J V Siebers; R George; I Barani; M Hagan
Journal:  Med Phys       Date:  2009-09       Impact factor: 4.071

2.  The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy.

Authors:  Yasuhiro Dekura; Kentaro Nishioka; Takayuki Hashimoto; Naoki Miyamoto; Ryusuke Suzuki; Takaaki Yoshimura; Ryuji Matsumoto; Takahiro Osawa; Takashige Abe; Yoichi M Ito; Nobuo Shinohara; Hiroki Shirato; Shinichi Shimizu
Journal:  Radiat Oncol       Date:  2019-12-12       Impact factor: 3.481

  2 in total

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