Literature DB >> 17979800

Sphingolipid signaling pathways as potential therapeutic targets in gliomas.

James R Van Brocklyn1.   

Abstract

Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways.

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Year:  2007        PMID： 17979800     DOI： 10.2174/138955707782110123

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  21 in total

Review 1.  Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases.

Authors:  S M De La Monte
Journal:  Panminerva Med       Date:  2012-09       Impact factor: 5.197

2.  Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches.

Authors:  Jacqueline V Chapman; Valérie Gouazé-Andersson; Maria C Messner; Margaret Flowers; Ramin Karimi; Mark Kester; Brian M Barth; Xin Liu; Yong-Yu Liu; Armando E Giuliano; Myles C Cabot
Journal:  Biochem Pharmacol       Date:  2010-04-10       Impact factor: 5.858

Review 3.  Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed.

Authors:  Suzanne M de la Monte
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

4.  Ceramide-mediated insulin resistance and impairment of cognitive-motor functions.

Authors:  Suzanne M de la Monte; Ming Tong; VanAnh Nguyen; Mashiko Setshedi; Lisa Longato; Jack R Wands
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

Review 5.  Alcohol, insulin resistance and the liver-brain axis.

Authors:  Suzanne de la Monte; Zoltan Derdak; Jack R Wands
Journal:  J Gastroenterol Hepatol       Date:  2012-03       Impact factor: 4.029

6.  Cerebrovascular Angiogenic Reprogramming upon LRP1 Repression: Impact on Sphingosine-1-Phosphate-Mediated Signaling in Brain Endothelial Cell Chemotactism.

Authors:  Amélie Vézina; Cyndia Charfi; Alain Zgheib; Borhane Annabi
Journal:  Mol Neurobiol       Date:  2017-05-17       Impact factor: 5.590

Review 7.  Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

Authors:  Suzanne M de la Monte; Lisa Longato; Ming Tong; Jack R Wands
Journal:  Curr Opin Investig Drugs       Date:  2009-10

8.  Ceramide signaling in cancer and stem cells.

Authors:  Erhard Bieberich
Journal:  Future Lipidol       Date:  2008-06

9.  Mechanisms of ceramide-mediated neurodegeneration.

Authors:  Ming Tong; Suzanne M de la Monte
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

Review 10.  The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids.

Authors:  Suzanne M de la Monte; Lisa Longato; Ming Tong; Sarah DeNucci; Jack R Wands
Journal:  Int J Environ Res Public Health       Date:  2009-07-23       Impact factor: 3.390
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