Literature DB >> 19777393

Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

Suzanne M de la Monte1, Lisa Longato, Ming Tong, Jack R Wands.   

Abstract

Recent studies have linked obesity, type 2 diabetes mellitus (T2DM) or non-alcoholic steatohepatitis (NASH) to insulin resistance in the brain, cognitive impairment and neurodegeneration. Insulin resistance compromises cell survival, metabolism and neuronal plasticity, and increases oxidative stress, cytokine activation and apoptosis. T2DM/NASH has been demonstrated to be associated with increased ceramide generation, suggesting a mechanistic link between peripheral insulin resistance and neurodegeneration because ceramides mediate insulin resistance and can cross the blood-brain barrier (BBB). Peripheral insulin resistance diseases may potentially cause brain insulin resistance via a liver-brain axis of neurodegeneration as a result of the trafficking of ceramides across the BBB. Therapy that includes insulin-sensitizing agents may help prevent brain insulin resistance-mediated cognitive impairment.

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Year:  2009        PMID： 19777393      PMCID： PMC4600072     

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  173 in total

Review 1.  Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.

Authors:  A Virkamäki; K Ueki; C R Kahn
Journal:  J Clin Invest       Date:  1999-04       Impact factor: 14.808

2.  Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease.

Authors:  Suzanne M de la Monte; Jack R Wands
Journal:  J Alzheimers Dis       Date:  2006-07       Impact factor: 4.472

3.  Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion.

Authors:  Tatiane C A Nogueira; Gabriel F Anhê; Carla R O Carvalho; Rui Curi; Silvana Bordin; Angelo R Carpinelli
Journal:  Pancreas       Date:  2008-10       Impact factor: 3.327

4.  Mechanisms of ceramide-mediated neurodegeneration.

Authors:  Ming Tong; Suzanne M de la Monte
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

5.  beta-Conglycinins among sources of bioactives in hydrolysates of different soybean varieties that inhibit leukemia cells in vitro.

Authors:  Wenyi Wang; Neal A Bringe; Mark A Berhow; Elvira Gonzalez de Mejia
Journal:  J Agric Food Chem       Date:  2008-05-13       Impact factor: 5.279

6.  Insulin resistance in experimental alcohol-induced liver disease.

Authors:  Suzanne M de la Monte; Jong-Eun Yeon; Ming Tong; Lisa Longato; Rajeev Chaudhry; Mao-Yin Pang; Kevin Duan; Jack R Wands
Journal:  J Gastroenterol Hepatol       Date:  2008-05-26       Impact factor: 4.029

7.  IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.

Authors:  Susanna Freude; Uschi Leeser; Marita Müller; Moritz M Hettich; Michael Udelhoven; Katharina Schilbach; Kazuyuki Tobe; Takashi Kadowaki; Christoph Köhler; Hannsjörg Schröder; Wilhelm Krone; Jens C Brüning; Markus Schubert
Journal:  J Neurochem       Date:  2008-09-18       Impact factor: 5.372

Review 8.  Altered lipid metabolism in brain injury and disorders.

Authors:  Rao Muralikrishna Adibhatla; J F Hatcher
Journal:  Subcell Biochem       Date:  2008

Review 9.  Sphingolipids: players in the pathology of metabolic disease.

Authors:  L Ashley Cowart
Journal:  Trends Endocrinol Metab       Date:  2008-11-13       Impact factor: 12.015

10.  Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?

Authors:  Pavel Katsel; Celeste Li; Vahram Haroutunian
Journal:  Neurochem Res       Date:  2007-03-07       Impact factor: 3.996
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  73 in total

1.  Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzheimer's disease.

Authors:  Suzanne M de la Monte; Edward Re; Lisa Longato; Ming Tong
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

2.  Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory.

Authors:  Rosie G Albarran-Zeckler; Alicia Faruzzi Brantley; Roy G Smith
Journal:  Behav Brain Res       Date:  2012-03-31       Impact factor: 3.332

Review 3.  Brain metabolic dysfunction at the core of Alzheimer's disease.

Authors:  Suzanne M de la Monte; Ming Tong
Journal:  Biochem Pharmacol       Date:  2013-12-28       Impact factor: 5.858

4.  Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits.

Authors:  Jogender Mehla; Balwantsinh C Chauhan; Neelima B Chauhan
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

Review 5.  Minireview: Food for thought: regulation of synaptic function by metabolic hormones.

Authors:  Gemma McGregor; Yasaman Malekizadeh; Jenni Harvey
Journal:  Mol Endocrinol       Date:  2015-01

Review 6.  Autonomic Regulation of Glucose Homeostasis: a Specific Role for Sympathetic Nervous System Activation.

Authors:  Revathy Carnagarin; Vance B Matthews; Lakshini Y Herat; Jan K Ho; Markus P Schlaich
Journal:  Curr Diab Rep       Date:  2018-09-19       Impact factor: 4.810

Review 7.  Relationships between diabetes and cognitive impairment.

Authors:  Suzanne M de la Monte
Journal:  Endocrinol Metab Clin North Am       Date:  2013-12-12       Impact factor: 4.741

Review 8.  Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art.

Authors:  Suzanne M de la Monte
Journal:  Expert Opin Drug Deliv       Date:  2013-11-12       Impact factor: 6.648

9.  Altered temporal lobe white matter lipid ion profiles in an experimental model of sporadic Alzheimer's disease.

Authors:  Ming Tong; Raiane Leão; Gina V Vimbela; Emine B Yalcin; Jared Kay; Alexander Krotow; Suzanne M de la Monte
Journal:  Mol Cell Neurosci       Date:  2017-04-21       Impact factor: 4.314

10.  Impairment of Novel Object Recognition Memory and Brain Insulin Signaling in Fructose- but Not Glucose-Drinking Female Rats.

Authors:  Gemma Sangüesa; Mar Cascales; Christian Griñán; Rosa María Sánchez; Núria Roglans; Mercè Pallàs; Juan Carlos Laguna; Marta Alegret
Journal:  Mol Neurobiol       Date:  2018-01-26       Impact factor: 5.590
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