OBJECTIVE: We developed an epidural cooling catheter containing cold saline solution circulating in an isolated lumen. After placement by a minimally invasive approach, we evaluated protection effect against ischemic spinal cord injury in pigs. METHODS: Fourteen pigs underwent thoracic aortic double clamping for 45 minutes under systemic mild hypothermia (36 degrees C). Group A (n = 7) underwent local hypothermia with the cooling catheter. Group B (n = 7) underwent catheter placement only, without cooling. Spinal cord somatosensory evoked potentials were recorded to assess electrophysiologic status. Neurologic function was evaluated with a modified Tarlov score. RESULTS: At aortic crossclamping, spinal temperature in group A (26.5 degrees C +/- 2.4 degrees C) was significantly lower than that in group B (35.3 degrees C +/- 0.6 degrees C, P = .0001). Mean time from aortic crossclamping to onset of potential loss was significantly longer in group A (28.4 +/- 6.6 minutes) than in group B (18.3 +/- 5.0 minutes, P = .007). Mean duration of total loss of potentials was significantly shorter in group A (19.0 +/- 6.7 minutes) than that in group B (31.3 +/- 5.9 minutes, P = .003). Group A showed significantly better neurologic function (mean Tarlov score 4.4 +/- 0.8) than that of group B (0.1 +/- 0.4, P = .0001). Mean total number of intact motor neurons was significantly greater in group A (24.5 +/- 6.8) than that of group B (9.9 +/- 6.8, P = .0001). CONCLUSION: By cooling the spinal cord selectively and continuously, the newly designed epidural cooling catheter prevented ischemic injury in a pig model of aortic crossclamping.
OBJECTIVE: We developed an epidural cooling catheter containing cold saline solution circulating in an isolated lumen. After placement by a minimally invasive approach, we evaluated protection effect against ischemic spinal cord injury in pigs. METHODS: Fourteen pigs underwent thoracic aortic double clamping for 45 minutes under systemic mild hypothermia (36 degrees C). Group A (n = 7) underwent local hypothermia with the cooling catheter. Group B (n = 7) underwent catheter placement only, without cooling. Spinal cord somatosensory evoked potentials were recorded to assess electrophysiologic status. Neurologic function was evaluated with a modified Tarlov score. RESULTS: At aortic crossclamping, spinal temperature in group A (26.5 degrees C +/- 2.4 degrees C) was significantly lower than that in group B (35.3 degrees C +/- 0.6 degrees C, P = .0001). Mean time from aortic crossclamping to onset of potential loss was significantly longer in group A (28.4 +/- 6.6 minutes) than in group B (18.3 +/- 5.0 minutes, P = .007). Mean duration of total loss of potentials was significantly shorter in group A (19.0 +/- 6.7 minutes) than that in group B (31.3 +/- 5.9 minutes, P = .003). Group A showed significantly better neurologic function (mean Tarlov score 4.4 +/- 0.8) than that of group B (0.1 +/- 0.4, P = .0001). Mean total number of intact motor neurons was significantly greater in group A (24.5 +/- 6.8) than that of group B (9.9 +/- 6.8, P = .0001). CONCLUSION: By cooling the spinal cord selectively and continuously, the newly designed epidural cooling catheter prevented ischemic injury in a pig model of aortic crossclamping.
Authors: Ashwati Vipin; Jukka Kortelainen; Hasan Al-Nashash; Soo Min Chua; Xinyuan Thow; Janani Manivannan; Nitish V Thakor; Candace L Kerr; Angelo H All Journal: Ther Hypothermia Temp Manag Date: 2015-06-09 Impact factor: 1.286
Authors: Stefania Gedrova; Jan Galik; Martin Marsala; Monika Zavodska; Jaroslav Pavel; Igor Sulla; Miroslav Gajdos; Imrich Lukac; Jozef Kafka; Valent Ledecky; Igor Sulla; Martina Karasova; Peter Reichel; Alexandra Trbolova; Igor Capik; Viktoria Lukacova; Katarina Bimbova; Maria Bacova; Andrea Stropkovska; Nadezda Lukacova Journal: Exp Ther Med Date: 2017-11-01 Impact factor: 2.447