BACKGROUND AND AIM: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. METHODS: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. RESULTS: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. CONCLUSION: Our findings suggest that snmMCI may be considered a vascular cognitive disorder. (c) 2007 S. Karger AG, Basel.
BACKGROUND AND AIM: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. METHODS: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. RESULTS: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. CONCLUSION: Our findings suggest that snmMCI may be considered a vascular cognitive disorder. (c) 2007 S. Karger AG, Basel.
Authors: Amy J Jak; Katherine J Bangen; Christina E Wierenga; Lisa Delano-Wood; Jody Corey-Bloom; Mark W Bondi Journal: Int Rev Neurobiol Date: 2009 Impact factor: 3.230
Authors: Rosebud O Roberts; Yonas E Geda; David S Knopman; Ruth H Cha; Bradley F Boeve; Robert J Ivnik; Vernon Shane Pankratz; Eric G Tangalos; Ronald C Petersen Journal: Alzheimer Dis Assoc Disord Date: 2010 Jan-Mar Impact factor: 2.703
Authors: David P Sheppard; Jennifer E Iudicello; Mark W Bondi; Katie L Doyle; Erin E Morgan; Paul J Massman; Paul E Gilbert; Steven Paul Woods Journal: J Neurovirol Date: 2015-07-03 Impact factor: 2.643
Authors: Rosebud O Roberts; David S Knopman; Yonas E Geda; Ruth H Cha; Véronique L Roger; Ronald C Petersen Journal: Neurobiol Aging Date: 2008-12-16 Impact factor: 4.673
Authors: David S Knopman; Rosebud O Roberts; Yonas E Geda; Bradley F Boeve; V Shane Pankratz; Ruth H Cha; Eric G Tangalos; Robert J Ivnik; Ronald C Petersen Journal: Arch Neurol Date: 2009-05