OBJECTIVE: To determine the prevalence and types of cognitive impairment in a sample of nondemented participants aged ≥90 (the oldest-old) and to examine the relationships between cognitive impairment and cardiovascular risk factors. PARTICIPANTS: The participants were 420 nondemented individuals from The 90+ Study, a study of aging and dementia in the oldest-old. These participants were categorized into four nonoverlapping groups: normal cognition, amnestic mild cognitive impairment (aMCI), nonamnestic MCI (naMCI), and other cognitive impairment (OCI). History of cardiovascular risk factors was assessed through self-report. RESULTS: The overall prevalence of cognitive impairment in nondemented participants was 34.0% (95% CI: 29.5-38.5). The prevalence of OCI was highest (17.4%; 95% CI: 13.9-21.4), followed by aMCI (8.3%; 95% CI: 5.9-11.4) and naMCI (8.3%; 95% CI: 5.9-11.4). Normal cognition was present in 66.0% (95% CI: 61.2-70.5) of participants. History of hypertension and stroke were the only risk factors that varied between the groups, occurring more frequently in participants with naMCI (χ(2) = 3.82; P < .05) and OCI (χ(2) = 5.51; P < .05). CONCLUSIONS: This study found a high prevalence of cognitive impairment in a sample of nondemented oldest-old. We did not find a strong relationship between cardiovascular risk factors and the cognitive impairment groups, other than between hypertension and naMCI and stroke and OCI. Future studies comparing the incidence of dementia in these groups will ultimately determine their predictive utility in the oldest-old. Copyright Â
OBJECTIVE: To determine the prevalence and types of cognitive impairment in a sample of nondemented participants aged ≥90 (the oldest-old) and to examine the relationships between cognitive impairment and cardiovascular risk factors. PARTICIPANTS: The participants were 420 nondemented individuals from The 90+ Study, a study of aging and dementia in the oldest-old. These participants were categorized into four nonoverlapping groups: normal cognition, amnestic mild cognitive impairment (aMCI), nonamnestic MCI (naMCI), and other cognitive impairment (OCI). History of cardiovascular risk factors was assessed through self-report. RESULTS: The overall prevalence of cognitive impairment in nondemented participants was 34.0% (95% CI: 29.5-38.5). The prevalence of OCI was highest (17.4%; 95% CI: 13.9-21.4), followed by aMCI (8.3%; 95% CI: 5.9-11.4) and naMCI (8.3%; 95% CI: 5.9-11.4). Normal cognition was present in 66.0% (95% CI: 61.2-70.5) of participants. History of hypertension and stroke were the only risk factors that varied between the groups, occurring more frequently in participants with naMCI (χ(2) = 3.82; P < .05) and OCI (χ(2) = 5.51; P < .05). CONCLUSIONS: This study found a high prevalence of cognitive impairment in a sample of nondemented oldest-old. We did not find a strong relationship between cardiovascular risk factors and the cognitive impairment groups, other than between hypertension and naMCI and stroke and OCI. Future studies comparing the incidence of dementia in these groups will ultimately determine their predictive utility in the oldest-old. Copyright Â
Authors: Philippe P Pioggiosi; Domenico Berardi; Barbara Ferrari; Roberto Quartesan; Diana De Ronchi Journal: Brain Res Bull Date: 2005-11-10 Impact factor: 4.077
Authors: Lise Bathum; Lene Christiansen; Bernard Jeune; James Vaupel; Matt McGue; Kaare Christensen Journal: J Am Geriatr Soc Date: 2006-04 Impact factor: 5.562
Authors: P Fischer; S Jungwirth; S Zehetmayer; S Weissgram; S Hoenigschnabl; E Gelpi; W Krampla; K H Tragl Journal: Neurology Date: 2007-01-23 Impact factor: 9.910
Authors: I Skoog; C Hesse; O Aevarsson; S Landahl; J Wahlström; P Fredman; K Blennow Journal: J Neurol Neurosurg Psychiatry Date: 1998-01 Impact factor: 10.154
Authors: R Gessner; F M Reischies; A Kage; B Geiselmann; M Borchelt; E Steinhagen-Thiessen; E Köttgen Journal: Neurosci Lett Date: 1997-01-24 Impact factor: 3.046
Authors: Brittany N Dugger; Michael Malek-Ahmadi; Sarah E Monsell; Walter A Kukull; Bryan K Woodruff; Eric M Reiman; Thomas G Beach; Jeffrey Wilson Journal: Alzheimer Dis Assoc Disord Date: 2016 Jul-Sep Impact factor: 2.703
Authors: Mary Ganguli; Ching-Wen Lee; Beth E Snitz; Tiffany F Hughes; Eric McDade; Chung-Chou H Chang Journal: Neurology Date: 2014-12-03 Impact factor: 9.910
Authors: Costantino Iadecola; Kristine Yaffe; José Biller; Lisa C Bratzke; Frank M Faraci; Philip B Gorelick; Martha Gulati; Hooman Kamel; David S Knopman; Lenore J Launer; Jane S Saczynski; Sudha Seshadri; Adina Zeki Al Hazzouri Journal: Hypertension Date: 2016-10-10 Impact factor: 10.190
Authors: Rosebud O Roberts; Ruth H Cha; Michelle M Mielke; Yonas E Geda; Bradley F Boeve; Mary M Machulda; David S Knopman; Ronald C Petersen Journal: Neurology Date: 2015-04-08 Impact factor: 9.910
Authors: Claudia B Padula; Julie C Weitlauf; Allyson C Rosen; Gayle Reiber; Barbara B Cochrane; Michelle J Naughton; Wenjun Li; Michelle Rissling; Kristine Yaffe; Julie R Hunt; Marcia L Stefanick; Mary K Goldstein; Mark A Espeland Journal: Gerontologist Date: 2015-11-27
Authors: Mara A Schonberg; Christine E Kistler; Larissa Nekhlyudov; Angela Fagerlin; Roger B Davis; Christina C Wee; Edward R Marcantonio; Carmen L Lewis; Whitney A Stanley; Trisha M Crutchfield; Mary Beth Hamel Journal: J Clin Trials Date: 2014
Authors: John L Robinson; Laura Molina-Porcel; Maria M Corrada; Kevin Raible; Edward B Lee; Virginia M-Y Lee; Claudia H Kawas; John Q Trojanowski Journal: Brain Date: 2014-07-09 Impact factor: 13.501