OBJECTIVE: To evaluate the effect of topical 2% dorzolamide alone, and in combination with topical 0.5% timolol, on intraocular pressure (IOP) in normal cats. ANIMALS: Twenty-four healthy Domestic Short-haired cats. PROCEDURE: Baseline values of IOP were established at 7 am, 10 am, 1 pm, 5 pm and 9 pm during pretreatment phase (days 1-2). During treatment phase (days 3-10) cats received 2% dorzolamide HCl q 12 h in group A (n = 6), q 8 h in group B (n = 6), and combined with 0.5% timolol maleate q 12 h in group C (n = 6). Cats in control group D (n = 6) received artificial tears q 8 h. During treatment phase IOP measurements were continued at the same time-points as in the pretreatment phase. RESULTS: Mean pretreatment IOP in all cats was 18.46 +/- 2.99 mmHg. Mean IOP decreased significantly (P < 0.0086) in all treatment groups compared to pretreatment values (group A: 16.40 +/- 0.49 mmHg, group B: 16.04 +/- 0.49 mmHg, group C: 17.76 +/- 0.49 mmHg). IOP did not decrease in control group D (18.55 +/- 0.49 mmHg). The difference in IOP between treatment groups (A, B, C) was not statistically significant, but comparison of IOP between each treatment group and the control group was statistically significant (A-D; P = 0.0057; B-D, P = 0.0012; C-D, P = 0.0212). CONCLUSION: Topical 2% dorzolamide significantly lowers IOP in normal cats but the effect is mild. Concomitant application of 2% dorzolamide and 0.5% timolol does significantly decrease IOP, but the effect is not significantly greater than q 8 h administration of dorzolamide alone.
OBJECTIVE: To evaluate the effect of topical 2% dorzolamide alone, and in combination with topical 0.5% timolol, on intraocular pressure (IOP) in normal cats. ANIMALS: Twenty-four healthy Domestic Short-haired cats. PROCEDURE: Baseline values of IOP were established at 7 am, 10 am, 1 pm, 5 pm and 9 pm during pretreatment phase (days 1-2). During treatment phase (days 3-10) cats received 2% dorzolamide HCl q 12 h in group A (n = 6), q 8 h in group B (n = 6), and combined with 0.5% timolol maleate q 12 h in group C (n = 6). Cats in control group D (n = 6) received artificial tears q 8 h. During treatment phase IOP measurements were continued at the same time-points as in the pretreatment phase. RESULTS: Mean pretreatment IOP in all cats was 18.46 +/- 2.99 mmHg. Mean IOP decreased significantly (P < 0.0086) in all treatment groups compared to pretreatment values (group A: 16.40 +/- 0.49 mmHg, group B: 16.04 +/- 0.49 mmHg, group C: 17.76 +/- 0.49 mmHg). IOP did not decrease in control group D (18.55 +/- 0.49 mmHg). The difference in IOP between treatment groups (A, B, C) was not statistically significant, but comparison of IOP between each treatment group and the control group was statistically significant (A-D; P = 0.0057; B-D, P = 0.0012; C-D, P = 0.0212). CONCLUSION: Topical 2% dorzolamide significantly lowers IOP in normal cats but the effect is mild. Concomitant application of 2% dorzolamide and 0.5% timolol does significantly decrease IOP, but the effect is not significantly greater than q 8 h administration of dorzolamide alone.
Authors: Jessica E McDonald; Julie A Kiland; Paul L Kaufman; Ellison Bentley; N Matthew Ellinwood; Gillian J McLellan Journal: Vet Ophthalmol Date: 2015-07-16 Impact factor: 1.644
Authors: Kelly J Sigle; Gabriel Camaño-Garcia; Alicia L Carriquiry; Daniel M Betts; Markus H Kuehn; Gillian J McLellan Journal: Vet Ophthalmol Date: 2011-09 Impact factor: 1.644
Authors: Inge J M Slenter; Sylvia C Djajadiningrat-Laanen; Daphne J Elders; Reinoud de Gee; Linda E Koele; Loes W Vermeer; Michael H Boevé Journal: Vet Ophthalmol Date: 2019-05-17 Impact factor: 1.644