Literature DB >> 17972102

Parental transmission of HLA-DRB1*15 in multiple sclerosis.

Sreeram V Ramagopalan1, Blanca M Herrera, Jordana T Bell, David A Dyment, Gabriele C Deluca, Matthew R Lincoln, Sarah M Orton, Michael J Chao, A Dessa Sadovnick, George C Ebers.   

Abstract

Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.

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Year:  2007        PMID： 17972102     DOI： 10.1007/s00439-007-0442-z

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  18 in total

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  14 in total

1.  MHC transmission: insights into gender bias in MS susceptibility.

Authors:  M J Chao; S V Ramagopalan; B M Herrera; S M Orton; L Handunnetthi; M R Lincoln; D A Dyment; A D Sadovnick; G C Ebers
Journal:  Neurology       Date:  2011-01-05       Impact factor: 9.910

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Review 3.  Type 1 diabetes mellitus and multiple sclerosis: common etiological features.

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Review 4.  The fine balance of chemokines during disease: trafficking, inflammation, and homeostasis.

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7.  Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes.

Authors:  P G Bronson; P P Ramsay; G Thomson; L F Barcellos
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9.  Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.

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