Literature DB >> 17971734

Synthesis of conformationally constrained aryl- or heteroarylpiperazinyl derivatives of selected imides as 5-HT1A receptor ligands.

Jerzy Kossakowski1, Mariola Krawiecka, Bozena Kuran.   

Abstract

The preparation of a number of cyclic imide 5-HT(1A) receptor ligand derivatives has been described. Their structures were conformationally constrained by introducing rigid linkers containing unsaturated bonds or aromatic benzene rings. These compounds are expected to possess anxiolytic and antidepressant activity.

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Year:  2006        PMID： 17971734      PMCID： PMC6148633          DOI： 10.3390/11080615

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  9 in total

1.  Synthesis of new derivatives of 1,2,3,4,7-pentamethylbicyclo[2.2.1]hept-2-ene-5,6-dicarboximide with an expected anxiolytic activity.

Authors:  J Kossakowski; J Kuśmierczyk
Journal:  Pharmazie       Date:  2000-01       Impact factor: 1.267

2.  Synthesis of new n-substituted cyclic imides with potential anxiolytic activity. XVIII. Derivatives of 1-bromo-dibenzo[e.h]bicyclo[2.2.2] octane-2.3-dicarboximide.

Authors:  J Kossakowski; M Perliński
Journal:  Acta Pol Pharm       Date:  2001 Jul-Aug       Impact factor: 0.330

3.  Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XV. Derivatives of 2-ethyl-1.4-dimethoxy-dibenzo[e.h]bicyclo[2.2.2] octane-2.3-dicarboximide.

Authors:  J Kossakowski; E Maleszewska
Journal:  Acta Pol Pharm       Date:  2000-11       Impact factor: 0.330

4.  Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XI. Derivatives of 7-diphenylmethylenebicyclo[2.2.1]hept-2-ene-5,6-dicarboximide.

Authors:  J Kossakowski; E Hejchman
Journal:  Acta Pol Pharm       Date:  2000-11       Impact factor: 0.330

5.  Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XII. Derivatives of N-hydroxy-1,4-dimethyl-dibenzo[e.h]bicyclo[2.2.2]-octane-2,3-dicarboximide.

Authors:  J Kossakowski; M Jarocka
Journal:  Acta Pol Pharm       Date:  2000-11       Impact factor: 0.330

6.  Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XIII. Derivatives of 1-methoxybicyclo[2.2.2]oct-5-ene-2,3-dicarboximide.

Authors:  J Kossakowski; M Krawiecka
Journal:  Acta Pol Pharm       Date:  2000-11       Impact factor: 0.330

7.  The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.

Authors:  Andrzej J Bojarski; Beata Duszyńska; Marcin Kołaczkowski; Piotr Kowalski; Teresa Kowalska
Journal:  Bioorg Med Chem Lett       Date:  2004-12-06       Impact factor: 2.823

8.  Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity.

Authors:  Andrzej J Bojarski; Maria H Paluchowska; Beata Duszyńska; Ryszard Bugno; Aleksandra Kłodzińska; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik
Journal:  Bioorg Med Chem       Date:  2005-11-02       Impact factor: 3.641

Review 9.  Structure-activity relationships at 5-HT1A receptors: binding profiles and intrinsic activity.

Authors:  D L Nelson
Journal:  Pharmacol Biochem Behav       Date:  1991-12       Impact factor: 3.533
  9 in total
  1 in total

1.  Structural examination of ring-closing metathesis-derived 15-member macrocycles as Grb2 SH2 domain-binding tetrapeptide mimetics.

Authors:  Fa Liu; Karen M Worthy; Lakshman K Bindu; Robert J Fisher; Terrence R Burke
Journal:  J Org Chem       Date:  2007-11-09       Impact factor: 4.354
  1 in total

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