| Literature DB >> 15501057 |
Andrzej J Bojarski1, Beata Duszyńska, Marcin Kołaczkowski, Piotr Kowalski, Teresa Kowalska.
Abstract
New cis-, trans-2-butene and 1,2-bismethylbenzene analogues of MM77 and NAN-190 (1-[4-[4-(2-methoxyphenyl)-piperazin-1-yl]-butyl]-pyrrolidine-2,5-dione and isoindole-1,3-dione, respectively) were synthesized. The differences in their in vitro affinity for serotonin 5-HT(7) and 5-HT(1A) receptors were explained using a conformational analysis. A bioactive conformation of those compounds for the 5-HT(7) receptor, different from that established for 5-HT(1A), was proposed.Entities:
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Year: 2004 PMID： 15501057 DOI： 10.1016/j.bmcl.2004.09.029
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823