Literature DB >> 17968643

Level of functioning in autism spectrum disorders: phenotypic congruence among affected siblings.

Robin P Goin-Kochel1, Carla A Mazefsky, Brien P Riley.   

Abstract

Little evidence supports that siblings with autism exhibit the same behaviors; however, some findings suggest that level of functioning shows familial aggregation. We tested this notion among multiplex families participating with the Autism Genetic Resource Exchange (AGRE) Consortium, using scores on the Peabody Picture Vocabulary Test-Third Edition (N = 204 families), the Ravens Colored Progressive Matrices (N = 226 families), and the Vineland Adaptive Behavior Scales (N = 348 families). Intraclass Correlation Coefficients revealed that siblings with autism/autism spectrum disorders (ASD) were more similar on measures of verbal and nonverbal IQ and adaptive functioning than were unrelated children with autism/ASD. Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others.

Entities:  

Mesh：

Year:  2007        PMID： 17968643      PMCID： PMC4104536          DOI： 10.1007/s10803-007-0476-z

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


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  11 in total

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