Literature DB >> 17967743

Sodium valproate does not augment Prpsc in murine neuroblastoma cells.

C Legendre1, F Casagrande, T Andrieu, D Dormont, P Clayette.   

Abstract

Sodium valproate (VPA) has been reported to increase the accumulation of the pathologic isoform of prion protein (PrPsc) in scrapie-infected murine neuroblastoma cells. In this study, the effect of VPA on PrPsc accumulation was investigated in murine N2a neuroblastoma cells chronically infected with scrapie strain 22L (N2a-22L). No accumulation of PrPsc was detected after short-term (3 days) or long-term (21 days) treatment of N2a-22L cells with 4.8, 12, 18 or 24 microM VPA. Higher VPA concentrations (240 and 600 microM) also failed to augment PrPsc expression. In conclusion, in our experimental conditions, no deleterious effect was induced by VPA on prions replication.

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Year:  2007        PMID： 17967743     DOI： 10.1007/bf03033916

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  11 in total

Review 1.  Interactions and conversions of prion protein isoforms.

Authors:  B Caughey; G J Raymond; M A Callahan; C Wong; G S Baron; L W Xiong
Journal:  Adv Protein Chem       Date:  2001

2.  Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease.

Authors:  C Korth; B C May; F E Cohen; S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

3.  Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes.

Authors:  Gerald S Baron; Kathy Wehrly; David W Dorward; Bruce Chesebro; Byron Caughey
Journal:  EMBO J       Date:  2002-03-01       Impact factor: 11.598

4.  Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3.

Authors:  Mar Pérez; Ana I Rojo; Francisco Wandosell; Javier Díaz-Nido; Jesús Avila
Journal:  Biochem J       Date:  2003-05-15       Impact factor: 3.857

5.  Isolation of drugs active against mammalian prions using a yeast-based screening assay.

Authors:  Stéphane Bach; Nicolas Talarek; Thibault Andrieu; Jean-Michel Vierfond; Yvette Mettey; Hervé Galons; Dominique Dormont; Laurent Meijer; Christophe Cullin; Marc Blondel
Journal:  Nat Biotechnol       Date:  2003-08-10       Impact factor: 54.908

Review 6.  Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.

Authors:  Wolfgang Löscher
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

7.  Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons.

Authors:  Anita C Hall; Angela Brennan; Robert G Goold; Karen Cleverley; Fiona R Lucas; Phillip R Gordon-Weeks; Patricia C Salinas
Journal:  Mol Cell Neurosci       Date:  2002-06       Impact factor: 4.314

Review 8.  Search for a common mechanism of mood stabilizers.

Authors:  Adrian J Harwood; Galila Agam
Journal:  Biochem Pharmacol       Date:  2003-07-15       Impact factor: 5.858

Review 9.  Anti-tumor mechanisms of valproate: a novel role for an old drug.

Authors:  Roman A Blaheta; Jindrich Cinatl
Journal:  Med Res Rev       Date:  2002-09       Impact factor: 12.944

Review 10.  Prion protein conversions: insight into mechanisms, TSE transmission barriers and strains.

Authors:  Byron Caughey
Journal:  Br Med Bull       Date:  2003       Impact factor: 4.291
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  2 in total

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Authors:  Théo Z Hirsch; Séverine Martin-Lannerée; Fabienne Reine; Julia Hernandez-Rapp; Laetitia Herzog; Michel Dron; Nicolas Privat; Bruno Passet; Sophie Halliez; Ana Villa-Diaz; Caroline Lacroux; Victor Klein; Stéphane Haïk; Olivier Andréoletti; Juan-Maria Torres; Jean-Luc Vilotte; Vincent Béringue; Sophie Mouillet-Richard
Journal:  Mol Neurobiol       Date:  2018-07-11       Impact factor: 5.590

Review 2.  Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases.

Authors:  Karolina Pierzynowska; Lidia Gaffke; Zuzanna Cyske; Michał Puchalski; Estera Rintz; Michał Bartkowski; Marta Osiadły; Michał Pierzynowski; Jagoda Mantej; Ewa Piotrowska; Grzegorz Węgrzyn
Journal:  Metab Brain Dis       Date:  2018-03-14       Impact factor: 3.584
  2 in total

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