| Literature DB >> 17967552 |
Koichi Tamano1, Motoaki Sano, Noriko Yamane, Yasunobu Terabayashi, Tomomi Toda, Misao Sunagawa, Hideaki Koike, Osamu Hatamoto, Genryou Umitsuki, Tadashi Takahashi, Yasuji Koyama, Ryoichi Asai, Keietsu Abe, Masayuki Machida.
Abstract
Transcriptome analysis revealed close relationship between solid-state cultivation and the transcriptional regulation of the genes on the non-syntenic blocks (NSBs), which were characterized by the comparison of Aspergillus oryzae genome with those of Aspergillus fumigatus and Aspergillus nidulans. Average expression ratio of the genes on NSBs in solid-state cultivation was significantly higher than that on the syntenic blocks (SBs). Of the induced genes, the genes relating to metabolism, which are highly enriched on NSBs, most contributed to the NSB-specific induction. The analysis using the SB- and NSB-genes that had sequence similarity between the two blocks significantly decreased the difference of average expression ratios between the two blocks. In spite of remarkably high averaged expression ratio of the NSB genes encoding extracellular enzymes, no induction of PKS and NRPS genes on NSBs were observed in solid-state cultivations. These results strongly suggest that the genes on NSBs play an important role on solid-state fermentation.Entities:
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Year: 2007 PMID： 17967552 DOI： 10.1016/j.fgb.2007.09.005
Source DB: PubMed Journal: Fungal Genet Biol ISSN： 1087-1845 Impact factor: 3.495