| Literature DB >> 17963373 |
Mark Furber1, Lilian Alcaraz, Janice E Bent, Armin Beyerbach, Keith Bowers, Martin Braddock, Moya V Caffrey, David Cladingboel, John Collington, David K Donald, Malbinder Fagura, Frank Ince, Elizabeth C Kinchin, Celine Laurent, Mandy Lawson, Timothy J Luker, Michael M P Mortimore, Austen D Pimm, Robert J Riley, Nicola Roberts, Mark Robertson, Jill Theaker, Philip V Thorne, Richard Weaver, Peter Webborn, Paul Willis.
Abstract
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.Entities:
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Year: 2007 PMID： 17963373 DOI： 10.1021/jm700949w
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446