Literature DB >> 17962769

First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.

Gernot A Eller1, Wolfgang Holzer.   

Abstract

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and 1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of the corresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene - an interesting building-block for thiophene azo dyes - are reported. Detailed spectroscopic investigations ((1)H-NMR, (13)C-NMR, MS, IR) of the obtained compounds are presented.

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Year:  2006        PMID: 17962769      PMCID: PMC6148543          DOI: 10.3390/11050371

Source DB:  PubMed          Journal:  Molecules        ISSN: 1420-3049            Impact factor:   4.411


  1 in total

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Authors:  M S Langley; S P Clissold
Journal:  Drugs       Date:  1988-02       Impact factor: 9.546

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Review 1.  The Gewald multicomponent reaction.

Authors:  Yijun Huang; Alexander Dömling
Journal:  Mol Divers       Date:  2010-02-27       Impact factor: 2.943

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Journal:  J Med Chem       Date:  2017-10-27       Impact factor: 7.446

3.  3-Amino-5-(piperidin-1-yl)thio-phene-2,4-dicarbonitrile.

Authors:  Wedad M Al-Adiwish; D Adan; Mohamed Ibrahim Mohamed Tahir; W A Yaacob; Mohammad B Kassim
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-12-17

4.  Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators.

Authors:  Bhimanna Kuppast; Katerina Spyridaki; Christophina Lynch; Yueshan Hu; George Liapakis; Gareth E Davies; Hesham Fahmy
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  4 in total

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