Literature DB >> 17962731

Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa.

Mankil Jung1, Moonso Park.   

Abstract

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).

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Year:  2007        PMID： 17962731      PMCID： PMC6149129          DOI： 10.3390/12092130

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


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