Literature DB >> 17959273

Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins.

Rajesh G Kalkhambkar1, Geeta M Kulkarni, Chandrappa M Kamanavalli, N Premkumar, S M B Asdaq, Chung Ming Sun.   

Abstract

A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17959273     DOI： 10.1016/j.ejmech.2007.08.007

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles.

Authors:  Kalicharan Chattopadhyay; Erik Fenster; Alexander J Grenning; Jon A Tunge
Journal:  Beilstein J Org Chem       Date:  2012-07-27       Impact factor: 2.883

2.  1,5-Dimethyl-3-[(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)meth-yl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dione.

Authors:  Rachida Dardouri; Youssef Kandri Rodi; Nathalie Saffon; Lahcen El Ammari; El Mokhtar Essassi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-30

3.  8-Formyl-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl-benzenesulfonate.

Authors:  H Yuvaraj; D Gayathri; Rajesh G Kalkhambkar; Geeta M Kulkarni; Rajendra M Bapset
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-25

4.  8-[(Hydrazinyl-idene)meth-yl]-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl-benzene-sulfonate.

Authors:  H Yuvaraj; D Gayathri; Rajesh G Kalkhambkar; G M Kulkarni; Rajendra M Bapset
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-12

5.  Antinociceptive properties of new coumarin derivatives bearing substituted 3,4-dihydro-2H-benzothiazines.

Authors:  Masoumeh Alipour; Mehdi Khoobi; Saeed Emami; Saeed Fallah-Benakohal; Seyedeh Farnaz Ghasemi-Niri; Mohammad Abdollahi; Alireza Foroumadi; Abbas Shafiee
Journal:  Daru       Date:  2014-01-07       Impact factor: 3.117

6.  Crystal structure and Hirshfeld surface analysis of 3,4-dihydro-2-(2,4-dioxo-6-methylpyran-3-ylidene)-4-(4-pyridin-4-yl)-1,5-benzodiazepine.

Authors:  Lhoussaine El Ghayati; Youssef Ramli; Tuncer Hökelek; Mohamed Labd Taha; Joel T Mague; El Mokhtar Essassi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-01-01

7.  Total phenolic, flavonoid contents, and biological activities of stem extracts of Astragalus spinosus (Forssk.) Muschl. grown in Northern Border Province, Saudi Arabia.

Authors:  Naira Nayeem; Mohd Imran; Syed Mohammed Basheeruddin Asdaq; Syed Imam Rabbani; Farhan Ali Alanazi; Abdulhakeem S Alamri; Walaa F Alsanie; Majid Alhomrani
Journal:  Saudi J Biol Sci       Date:  2021-12-20       Impact factor: 4.219

8.  Pharmacological Evaluation and Docking Studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarin Derivatives as Cholinesterase Inhibitors.

Authors:  Ahsan Raza; Aamer Saeed; Aliya Ibrar; Muhammad Muddassar; Aftab Ahmed Khan; Jamshed Iqbal
Journal:  ISRN Pharmacol       Date:  2012-08-16

Review 9.  Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition.

Authors:  F Jerry Reen; José A Gutiérrez-Barranquero; María L Parages; Fergal O Gara
Journal:  Appl Microbiol Biotechnol       Date:  2018-02-01       Impact factor: 4.813
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.