Literature DB >> 17958301

Proton-dependent transporter gene lndJ confers resistance to landomycin E in Streptomyces globisporus.

I Ostash1, B Ostash, S Walker, V Fedorenko.   

Abstract

Sequence analysis of 2 kb BamHI-SmaI fragment of landomycin E (LaE) gene cluster in S. globisporus 1912 revealed one complete ORF marked as lndJ. Analysis of putative LndJ aminoacid sequence allowed us to suppose that it is proton-dependent antiporter which could be involved in resistance to LaE in the producing strain. Although disruption of lndJ had no significant influence on LaE production and resistance, it's overexpression in wild type and LaE overproducing strains led to qualitative changes in landomycins biosynthesis and increased resistance to LaE. These data support the hypothesis about involvement of lndJ gene in landomycins export.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17958301

Source DB:  PubMed          Journal:  Genetika        ISSN： 0016-6758


  6 in total

1.  Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136.

Authors:  B Ostash; I Ostash; L Zhu; M K Kharel; A Luzhetskiĭ; A Bechthold; S Walker; J Rohr; V Fedorenko
Journal:  Genetika       Date:  2010-05

2.  ABC transporter genes from Streptomyces ghanaensis moenomycin biosynthetic gene cluster: roles in antibiotic production and export.

Authors:  Bohdan Ostash; Emma Doud; Suzanne Walker
Journal:  Arch Microbiol       Date:  2012-06-21       Impact factor: 2.552

Review 3.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

4.  Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production.

Authors:  Bohdan Ostash; Yuriy Rebets; Maksym Myronovskyy; Olga Tsypik; Iryna Ostash; Oleksandr Kulachkovskyy; Yuriy Datsyuk; Tatsunosuke Nakamura; Suzanne Walker; Victor Fedorenko
Journal:  Microbiology (Reading)       Date:  2011-02-03       Impact factor: 2.777

5.  The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux.

Authors:  Vidya Dhote; Agata L Starosta; Daniel N Wilson; Kevin A Reynolds
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

6.  Mining and engineering exporters for titer improvement of macrolide biopesticides in Streptomyces.

Authors:  Liyang Chu; Shanshan Li; Zhuoxu Dong; Yanyan Zhang; Pinjiao Jin; Lan Ye; Xiangjing Wang; Wensheng Xiang
Journal:  Microb Biotechnol       Date:  2021-08-26       Impact factor: 5.813
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.