OBJECTIVE: To assess the relationship of age and basal FSH level to the genetic quality of the embryo and the association with IVF treatment outcome. DESIGN: Prospective observation study. SETTING: A major inner London fertility clinic in the United Kingdom. PATIENT(S): One hundred fifty-one women who underwent IVF treatment cycles in conjunction with preimplantation genetic diagnosis for aneuploidy screening before fresh embryo transfer, between July 2003 and July 2005. INTERVENTION(S): Basal FSH levels (days 2-4) were determined at an earlier cycle, and women were divided into two groups: high basal FSH (>or=10 IU/L) and low basal FSH (<10 IU/L). Chromosome analysis was performed on a single blastomere by using fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S): Percentage of aneuploid embryos. RESULT(S): The percentage of aneuploid embryos was not statistically significantly different between the high- (50.0%, n = 32) and low- (50.2%, n = 119) basal FSH groups. However, the percentage of aneuploid embryos was statistically significantly higher (56.2%, n = 109) for women aged >or=38 years, as compared with women <38 years of age (37.5%, n = 42), independent of basal FSH levels. CONCLUSION(S): Elevated basal FSH levels reflect lower ovarian reserve but have no association with genetic quality of embryos. The percentage of aneuploid embryos is increased with advanced maternal age.
OBJECTIVE: To assess the relationship of age and basal FSH level to the genetic quality of the embryo and the association with IVF treatment outcome. DESIGN: Prospective observation study. SETTING: A major inner London fertility clinic in the United Kingdom. PATIENT(S): One hundred fifty-one women who underwent IVF treatment cycles in conjunction with preimplantation genetic diagnosis for aneuploidy screening before fresh embryo transfer, between July 2003 and July 2005. INTERVENTION(S): Basal FSH levels (days 2-4) were determined at an earlier cycle, and women were divided into two groups: high basal FSH (>or=10 IU/L) and low basal FSH (<10 IU/L). Chromosome analysis was performed on a single blastomere by using fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S): Percentage of aneuploid embryos. RESULT(S): The percentage of aneuploid embryos was not statistically significantly different between the high- (50.0%, n = 32) and low- (50.2%, n = 119) basal FSH groups. However, the percentage of aneuploid embryos was statistically significantly higher (56.2%, n = 109) for women aged >or=38 years, as compared with women <38 years of age (37.5%, n = 42), independent of basal FSH levels. CONCLUSION(S): Elevated basal FSH levels reflect lower ovarian reserve but have no association with genetic quality of embryos. The percentage of aneuploid embryos is increased with advanced maternal age.
Authors: Helen M Picton; Kay Elder; Franchesca D Houghton; Judith A Hawkhead; Anthony J Rutherford; Jan E Hogg; Henry J Leese; Sarah E Harris Journal: Mol Hum Reprod Date: 2010-06-22 Impact factor: 4.025
Authors: Lori R Bernstein; Amelia C L Mackenzie; Se-Jin Lee; Charles L Chaffin; István Merchenthaler Journal: Endocrinology Date: 2015-12-29 Impact factor: 4.736
Authors: F Yarde; F J M Broekmans; K M van der Pal-de Bruin; Y Schönbeck; E R te Velde; A D Stein; L H Lumey Journal: Hum Reprod Date: 2013-08-21 Impact factor: 6.918