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Literature DB >> 17949055

Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.

Yunjiang Feng¹, Anthony R Carroll, Rama Addepalli, Gregory A Fechner, Vicky M Avery, Ronald J Quinn.

Abstract

A novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae, Cladophora socialis. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments. Both compounds showed potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), an enzyme involved in the regulation of insulin cell signaling. Compounds 1 and 2 had IC50 values of 3.7 and 1.7 microM, respectively.

Entities: Chemical Species

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Year: 2007 PMID： 17949055 DOI： 10.1021/np070225o

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

8 in total

Review 1. Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades.

Authors: Cheng-Shi Jiang; Lin-fu Liang; Yue-wei Guo
Journal: Acta Pharmacol Sin Date: 2012-09-03 Impact factor: 6.150

Review 2. Environmental Impact on Seaweed Phenolic Production and Activity: An Important Step for Compound Exploitation.

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Journal: Mar Drugs Date: 2021-04-26 Impact factor: 5.118

3. Antibacterial Oligomeric Polyphenols from the Green Alga Cladophora socialis.

Authors: Serge Lavoie; Anne Marie Sweeney-Jones; Nazia Mojib; Brandon Dale; Kerstin Gagaring; Case W McNamara; Cassandra L Quave; Katy Soapi; Julia Kubanek
Journal: J Org Chem Date: 2019-04-03 Impact factor: 4.354

Review 4. Seaweed Phenolics: From Extraction to Applications.

Authors: João Cotas; Adriana Leandro; Pedro Monteiro; Diana Pacheco; Artur Figueirinha; Ana M M Gonçalves; Gabriela Jorge da Silva; Leonel Pereira
Journal: Mar Drugs Date: 2020-07-24 Impact factor: 5.118

5. Protective Effect of Vanillic Acid against Hyperinsulinemia, Hyperglycemia and Hyperlipidemia via Alleviating Hepatic Insulin Resistance and Inflammation in High-Fat Diet (HFD)-Fed Rats.

Authors: Wen-Chang Chang; James Swi-Bea Wu; Chen-Wen Chen; Po-Ling Kuo; Hsu-Min Chien; Yuh-Tai Wang; Szu-Chuan Shen
Journal: Nutrients Date: 2015-12-02 Impact factor: 5.717

Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.

Review 1. Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades.

Review 2. Environmental Impact on Seaweed Phenolic Production and Activity: An Important Step for Compound Exploitation.

3. Antibacterial Oligomeric Polyphenols from the Green Alga Cladophora socialis.

Review 4. Seaweed Phenolics: From Extraction to Applications.

5. Protective Effect of Vanillic Acid against Hyperinsulinemia, Hyperglycemia and Hyperlipidemia via Alleviating Hepatic Insulin Resistance and Inflammation in High-Fat Diet (HFD)-Fed Rats.

6. Biological importance of marine algae.

Review 7. Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders.

Review 8. Osteoarthritis Is a Low-Grade Inflammatory Disease: Obesity's Involvement and Herbal Treatment.