| Literature DB >> 17945211 |
Kathryn T Iacono1, Amy L Brown, Mark I Greene, Sandra J Saouaf.
Abstract
The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced.Entities:
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Year: 2007 PMID： 17945211 PMCID： PMC2211739 DOI： 10.1016/j.yexmp.2007.08.014
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 3.362