UNLABELLED: Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. METHODS: Anion-exchange columns with bed volumes of 100-300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system. RESULTS: Activity of 7.4-22.2 MBq (0.2-0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk. CONCLUSION: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.
UNLABELLED: Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. METHODS: Anion-exchange columns with bed volumes of 100-300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system. RESULTS: Activity of 7.4-22.2 MBq (0.2-0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk. CONCLUSION: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.
Authors: Alexander I Veress; W Paul Segars; Jeffrey A Weiss; Benjamin M W Tsui; Grant T Gullberg Journal: IEEE Trans Med Imaging Date: 2006-12 Impact factor: 10.048
Authors: William P Segars; Benjamin M W Tsui; Eric C Frey; G Allan Johnson; Stuart S Berr Journal: Mol Imaging Biol Date: 2004 May-Jun Impact factor: 3.488
Authors: G A Kastis; M C Wu; S J Balzer; D W Wilson; L R Furenlid; G Stevenson; H B Barber; H H Barrett; J M Woolfenden; P Kelly; M Appleby Journal: IEEE Nucl Sci Symp Conf Rec (1997) Date: 2002-08-07