OBJECTIVES: To verify if there is influence of the vitamin C blood levels on oxidative stress markers in elderly people. In order to verify it, women from a public retirement home were compared to non-institutionalized ones; all of them were in healthy conditions. DESIGN AND METHODS: Vitamin C, albumin, reduced glutathione, malondialdehyde (MDA), protein carbonyls and delta-aminolevulinate dehydratase activity (ALA-D) were analyzed in older women either from a public retirement home (n=45) or non-institutionalized (n=22). RESULTS: The institutionalized ones showed significant decrease for vitamin C levels (p=0.002), ALA-D and MDA (p<0.05). Correlations were found between vitamin C and both albumin and ALA-D, also between ALA-D and both protein carbonyls and age. CONCLUSIONS: The institutionalized women presented decreased vitamin C, albumin, MDA and ALA-D compared to non-institutionalized. Thus, it could be suggested that vitamin C tends to protect blood thiolic proteins. Moreover, its blood delta-aminoevulinate dehydratase activity seemed to be an additional biomarker of oxidation stress in healthy elderly.
OBJECTIVES: To verify if there is influence of the vitamin C blood levels on oxidative stress markers in elderly people. In order to verify it, women from a public retirement home were compared to non-institutionalized ones; all of them were in healthy conditions. DESIGN AND METHODS: Vitamin C, albumin, reduced glutathione, malondialdehyde (MDA), protein carbonyls and delta-aminolevulinate dehydratase activity (ALA-D) were analyzed in older women either from a public retirement home (n=45) or non-institutionalized (n=22). RESULTS: The institutionalized ones showed significant decrease for vitamin C levels (p=0.002), ALA-D and MDA (p<0.05). Correlations were found between vitamin C and both albumin and ALA-D, also between ALA-D and both protein carbonyls and age. CONCLUSIONS: The institutionalized women presented decreased vitamin C, albumin, MDA and ALA-D compared to non-institutionalized. Thus, it could be suggested that vitamin C tends to protect blood thiolic proteins. Moreover, its blood delta-aminoevulinate dehydratase activity seemed to be an additional biomarker of oxidation stress in healthy elderly.
Authors: Carla Roberta Nunes Polachini; Roselia Maria Spanevello; Daniela Zanini; Jucimara Baldissarelli; Luciane Belmonte Pereira; Maria Rosa Chitolina Schetinger; Ivana Beatrice Mânica da Cruz; Charles Elias Assmann; Margarete Dulce Bagatini; Vera Maria Morsch Journal: Neurotox Res Date: 2015-12-21 Impact factor: 3.911
Authors: Marília Baierle; Sabrina N Nascimento; Angela M Moro; Natália Brucker; Fernando Freitas; Bruna Gauer; Juliano Durgante; Suelen Bordignon; Murilo Zibetti; Clarissa M Trentini; Marta M M F Duarte; Tilman Grune; Nicolle Breusing; Solange C Garcia Journal: Oxid Med Cell Longev Date: 2015-03-19 Impact factor: 6.543
Authors: Marília Baierle; Mariele F Charão; Gabriela Göethel; Anelise Barth; Rafael Fracasso; Guilherme Bubols; Elisa Sauer; Sarah C Campanharo; Rafael C C Rocha; Tatiana D Saint'Pierre; Suelen Bordignon; Murilo Zibetti; Clarissa M Trentini; Daiana S Avila; Adriana Gioda; Solange C Garcia Journal: Int J Environ Res Public Health Date: 2014-10-17 Impact factor: 3.390