OBJECTIVE: To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia. STUDY DESIGN: P-selectin Thr715Pro and E-selectin Serl28Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype. RESULTS: Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy. CONCLUSION: The polymorphisms tested are not associated with the risk of severe preeclampsia.
OBJECTIVE: To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia. STUDY DESIGN:P-selectin Thr715Pro and E-selectinSerl28Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype. RESULTS: Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy. CONCLUSION: The polymorphisms tested are not associated with the risk of severe preeclampsia.