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Literature DB >> 17938185

Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis.

Kim L Credito¹, Lois M Ednie, Peter C Appelbaum.

Abstract

Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC 50 of 0.125 microg/ml and an MIC 90 of 1 microg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2x MIC after 48 h.

Entities: Chemical

Mesh：

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Year: 2007 PMID： 17938185 PMCID： PMC2223873 DOI： 10.1128/AAC.00910-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. Time-kill studies of the antianaerobe activity of garenoxacin compared with those of nine other agents.

Authors: Kim L Credito; Michael R Jacobs; Peter C Appelbaum
Journal: Antimicrob Agents Chemother Date: 2003-04 Impact factor: 5.191

2. In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds.

Authors: Dianne B Hoellman; Linda M Kelly; Kim Credito; Lauren Anthony; Lois M Ednie; Michael R Jacobs; Peter C Appelbaum
Journal: Antimicrob Agents Chemother Date: 2002-01 Impact factor: 5.191

3. Time-kill study of the activity of trovafloxacin compared with ciprofloxacin, sparfloxacin, metronidazole, cefoxitin, piperacillin and piperacillin/tazobactam against six anaerobes.

Authors: S K Spangler; M R Jacobs; P C Appelbaum
Journal: J Antimicrob Chemother Date: 1997-06 Impact factor: 5.790

4. In vitro activities of doripenem and comparator agents against 364 anaerobic clinical isolates.

Authors: Hannah M Wexler; Adrian E Engel; Daniel Glass; Calida Li
Journal: Antimicrob Agents Chemother Date: 2005-10 Impact factor: 5.191

5. Beta-lactamase production, beta-lactam sensitivity and resistance to synergy with clavulanate of 737 Bacteroides fragilis group organisms from thirty-three US centres.

Authors: M R Jacobs; S K Spangler; P C Appelbaum
Journal: J Antimicrob Chemother Date: 1990-09 Impact factor: 5.790

6. Bactericidal activity of DU-6859a compared to activities of three quinolones, three beta-lactams, clindamycin, and metronidazole against anaerobes as determined by time-kill methodology.

Authors: S K Spangler; M R Jacobs; P C Appelbaum
Journal: Antimicrob Agents Chemother Date: 1997-04 Impact factor: 5.191

7. In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis.

Authors: Yunhua Chen; Elizabeth Garber; Qiuqu Zhao; Yigong Ge; Matthew A Wikler; Koné Kaniga; Lisa Saiman
Journal: Antimicrob Agents Chemother Date: 2005-06 Impact factor: 5.191

8. Susceptibilities of 394 Bacteroides fragilis, non-B. fragilis group Bacteroides species, and Fusobacterium species to newer antimicrobial agents.

Authors: P C Appelbaum; S K Spangler; M R Jacobs
Journal: Antimicrob Agents Chemother Date: 1991-06 Impact factor: 5.191

9. Susceptibility of 539 gram-positive and gram-negative anaerobes to new agents, including RP59500, biapenem, trospectomycin and piperacillin/tazobactam.

Authors: P C Appelbaum; S K Spangler; M R Jacobs
Journal: J Antimicrob Chemother Date: 1993-08 Impact factor: 5.790

Review 10. Quinolone activity against anaerobes: microbiological aspects.

Authors: P C Appelbaum
Journal: Drugs Date: 1995 Impact factor: 9.546

5 in total

1. Antianaerobic activity of sulopenem compared to six other agents.

Authors: Lois M Ednie; Peter C Appelbaum
Journal: Antimicrob Agents Chemother Date: 2009-02-17 Impact factor: 5.191

2. In vitro and in vivo activities of the novel Ketolide RBx 14255 against Clostridium difficile.

Authors: Manoj Kumar; Tarun Mathur; Tarani K Barman; G Ramkumar; Ashish Bhati; Gunjan Shukla; Vandana Kalia; Manisha Pandya; V Samuel Raj; Dilip J Upadhyay; Chetana Vaishnavi; Anjan Chakrabarti; Biswajit Das; Pradip K Bhatnagar
Journal: Antimicrob Agents Chemother Date: 2012-08-06 Impact factor: 5.191