UNLABELLED: To study the role of the GR gene on BMD regulation in the Chinese, a sex-specific association study was performed. The results indicated that GR variation contributed to the extreme BMD variation in the Chinese. INTRODUCTION: The glucocorticoid (GC) receptor (GR) gene is an important candidate gene for BMD regulation in GC-induced osteoporosis (GIO). However, no study has explored the genetic effects of the GR gene on BMD variation in the Chinese population. MATERIALS AND METHODS: Our sample consisted of 800 unrelated subjects (400 women and 400 men) with extreme age-adjusted hip BMD Z-scores selected from a population composed of 1988 normal adult Chinese Han. Four single nucleotide polymorphisms (SNPs) in the GR gene were genotyped. Both single SNP and haplotype association analyses were conducted. RESULTS: SNP rs1866388 (p(c) = 0.028) was found to be significantly associated with extreme BMD only in men. In both sexes, haplotypes involving rs1866388 and rs2918419 were found to have different frequency distributions in extremely low and high BMD groups (p(p) = 0.024, 0.001, and 0.002 in women and 0.002, 0.003, and 0.003 in men for window sizes of two, three, and four SNPs, respectively). Most shared haplotypes showed opposite effects between women and men. CONCLUSIONS: For the first time, our study suggested the possible role of the GR gene on BMD regulation and sex specificity in the association of GR with extreme BMD in the Chinese.
UNLABELLED: To study the role of the GR gene on BMD regulation in the Chinese, a sex-specific association study was performed. The results indicated that GR variation contributed to the extreme BMD variation in the Chinese. INTRODUCTION: The glucocorticoid (GC) receptor (GR) gene is an important candidate gene for BMD regulation in GC-induced osteoporosis (GIO). However, no study has explored the genetic effects of the GR gene on BMD variation in the Chinese population. MATERIALS AND METHODS: Our sample consisted of 800 unrelated subjects (400 women and 400 men) with extreme age-adjusted hip BMD Z-scores selected from a population composed of 1988 normal adult Chinese Han. Four single nucleotide polymorphisms (SNPs) in the GR gene were genotyped. Both single SNP and haplotype association analyses were conducted. RESULTS: SNP rs1866388 (p(c) = 0.028) was found to be significantly associated with extreme BMD only in men. In both sexes, haplotypes involving rs1866388 and rs2918419 were found to have different frequency distributions in extremely low and high BMD groups (p(p) = 0.024, 0.001, and 0.002 in women and 0.002, 0.003, and 0.003 in men for window sizes of two, three, and four SNPs, respectively). Most shared haplotypes showed opposite effects between women and men. CONCLUSIONS: For the first time, our study suggested the possible role of the GR gene on BMD regulation and sex specificity in the association of GR with extreme BMD in the Chinese.
Authors: J C Stephens; J A Schneider; D A Tanguay; J Choi; T Acharya; S E Stanley; R Jiang; C J Messer; A Chew; J H Han; J Duan; J L Carr; M S Lee; B Koshy; A M Kumar; G Zhang; W R Newell; A Windemuth; C Xu; T S Kalbfleisch; S L Shaner; K Arnold; V Schulz; C M Drysdale; K Nandabalan; R S Judson; G Ruano; G F Vovis Journal: Science Date: 2001-07-12 Impact factor: 47.728
Authors: Ching-Ti Liu; Karol Estrada; Laura M Yerges-Armstrong; Najaf Amin; Evangelos Evangelou; Guo Li; Ryan L Minster; Melanie A Carless; Candace M Kammerer; Ling Oei; Yanhua Zhou; Nerea Alonso; Zoe Dailiana; Joel Eriksson; Natalia García-Giralt; Sylvie Giroux; Lise Bjerre Husted; Rita I Khusainova; Theodora Koromila; Annie Waichee Kung; Joshua R Lewis; Laura Masi; Simona Mencej-Bedrac; Xavier Nogues; Millan S Patel; Janez Prezelj; J Brent Richards; Pak Chung Sham; Timothy Spector; Liesbeth Vandenput; Su-Mei Xiao; Hou-Feng Zheng; Kun Zhu; Susana Balcells; Maria Luisa Brandi; Morten Frost; David Goltzman; Jesús González-Macías; Magnus Karlsson; Elza K Khusnutdinova; Panagoula Kollia; Bente Lomholt Langdahl; Osten Ljunggren; Mattias Lorentzon; Janja Marc; Dan Mellström; Claes Ohlsson; José M Olmos; Stuart H Ralston; José A Riancho; François Rousseau; Roser Urreizti; Wim Van Hul; María T Zarrabeitia; Martha Castano-Betancourt; Serkalem Demissie; Elin Grundberg; Lizbeth Herrera; Tony Kwan; Carolina Medina-Gómez; Tomi Pastinen; Gunnar Sigurdsson; Gudmar Thorleifsson; Joyce Bj Vanmeurs; John Blangero; Albert Hofman; Yongmei Liu; Braxton D Mitchell; Jeffrey R O'Connell; Ben A Oostra; Jerome I Rotter; Kari Stefansson; Elizabeth A Streeten; Unnur Styrkarsdottir; Unnur Thorsteinsdottir; Frances A Tylavsky; Andre Uitterlinden; Jane A Cauley; Tamara B Harris; John Pa Ioannidis; Bruce M Psaty; John A Robbins; M Carola Zillikens; Cornelia M Vanduijn; Richard L Prince; David Karasik; Fernando Rivadeneira; Douglas P Kiel; L Adrienne Cupples; Yi-Hsiang Hsu Journal: J Bone Miner Res Date: 2012-10 Impact factor: 6.741
Authors: Anna L Swan; Christine Schütt; Jan Rozman; Maria Del Mar Muñiz Moreno; Stefan Brandmaier; Michelle Simon; Stefanie Leuchtenberger; Mark Griffiths; Robert Brommage; Piia Keskivali-Bond; Harald Grallert; Thomas Werner; Raffaele Teperino; Lore Becker; Gregor Miller; Ala Moshiri; John R Seavitt; Derek D Cissell; Terrence F Meehan; Elif F Acar; Christopher J Lelliott; Ann M Flenniken; Marie-France Champy; Tania Sorg; Abdel Ayadi; Robert E Braun; Heather Cater; Mary E Dickinson; Paul Flicek; Juan Gallegos; Elena J Ghirardello; Jason D Heaney; Sylvie Jacquot; Connor Lally; John G Logan; Lydia Teboul; Jeremy Mason; Nadine Spielmann; Colin McKerlie; Stephen A Murray; Lauryl M J Nutter; Kristian F Odfalk; Helen Parkinson; Jan Prochazka; Corey L Reynolds; Mohammed Selloum; Frantisek Spoutil; Karen L Svenson; Taylor S Vales; Sara E Wells; Jacqueline K White; Radislav Sedlacek; Wolfgang Wurst; K C Kent Lloyd; Peter I Croucher; Helmut Fuchs; Graham R Williams; J H Duncan Bassett; Valerie Gailus-Durner; Yann Herault; Ann-Marie Mallon; Steve D M Brown; Philipp Mayer-Kuckuk; Martin Hrabe de Angelis Journal: PLoS Genet Date: 2020-12-28 Impact factor: 6.020
Authors: Lucia Oton-Gonzalez; Chiara Mazziotta; Maria Rosa Iaquinta; Elisa Mazzoni; Riccardo Nocini; Lorenzo Trevisiol; Antonio D'Agostino; Mauro Tognon; John Charles Rotondo; Fernanda Martini Journal: Int J Mol Sci Date: 2022-01-28 Impact factor: 5.923