| Literature DB >> 17936628 |
H Sheridan1, S Butterly, J J Walsh, C Cogan, M Jordan, O Nolan, N Frankish.
Abstract
A series of N-substituted 3-aminoindanones were synthesised and evaluated for smooth muscle relaxant activity and mediator release inhibition effects. A low level of smooth muscle relaxant activity has been identified in all derivatives. Data have revealed that the significant mediator release inhibition effects observed are related to the nature of the amine substituents. A structure activity relationship is proposed.Entities:
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Year: 2007 PMID： 17936628 DOI： 10.1016/j.bmc.2007.09.041
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641