BACKGROUND: Several reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G --> T at nucleotide 894, exon 7) with essential hypertension (EHT). Findings, however are not uniform. In this case-control study, we determined the prevalence and distribution of the above polymorphism and their relationship with the disease to elucidate the association of this polymorphism with the risk and pathophysiology of EHT in the Asian Indians and significance of T allele in this context. METHODS: Two hundred normal controls and 226 patients with EHT from Delhi and surrounding areas were recruited for the investigation. Venous blood samples were used for genotyping. Genotyping was done by PCR-RFLP. RESULTS: The data suggested higher prevalence of GT+TT genotypes in patients as compared to the controls and association of T allele with EHT [p<0.001, odds ratio at 95% CI, 2.10 (1.34-3.28)]. CONCLUSIONS: Asian Indians of this region with T allele may be at higher risk of EHT.
BACKGROUND: Several reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G --> T at nucleotide 894, exon 7) with essential hypertension (EHT). Findings, however are not uniform. In this case-control study, we determined the prevalence and distribution of the above polymorphism and their relationship with the disease to elucidate the association of this polymorphism with the risk and pathophysiology of EHT in the Asian Indians and significance of T allele in this context. METHODS: Two hundred normal controls and 226 patients with EHT from Delhi and surrounding areas were recruited for the investigation. Venous blood samples were used for genotyping. Genotyping was done by PCR-RFLP. RESULTS: The data suggested higher prevalence of GT+TT genotypes in patients as compared to the controls and association of T allele with EHT [p<0.001, odds ratio at 95% CI, 2.10 (1.34-3.28)]. CONCLUSIONS: Asian Indians of this region with T allele may be at higher risk of EHT.
Authors: Norman E Buroker; Xue-Han Ning; Zhao-Nian Zhou; Kui Li; Wei-Jun Cen; Xiu-Feng Wu; Wei-Zhong Zhu; C Ronald Scott; Shi-Han Chen Journal: Int J Hematol Date: 2012-06-24 Impact factor: 2.490
Authors: Pascal L Kingah; Hung N Luu; Kelly A Volcik; Alanna C Morrison; Jennifer A Nettleton; Eric Boerwinkle Journal: Hypertens Res Date: 2009-12-04 Impact factor: 3.872
Authors: Nur Ilyana Jaafar; Ramachandran Vasudevan; Patimah Ismail; Ahmad Fazli Abdul Aziz; Nur Afiqah Mohamad; Geetha Kandavello; Raja Nurzatul Effah Raja Adnan; Vinod Balasubramaniam Journal: J Cardiovasc Dev Dis Date: 2018-09-18
Authors: Rafael Amorim Belo Nunes; Larissa Barbosa Lima; Nelson Ithiro Tanaka; Alexandre da Costa Pereira; José Eduardo Krieger; Alfredo José Mansur Journal: Int J Cardiol Heart Vasc Date: 2018-10-02