OBJECTIVE: To evaluate the influence of obesity, age, and years since menopause on bone density. METHODS: A retrospective analysis of bone mineral density (BMD) obtained from 588 women, 41 to 60 years, previously menopaused (1-10 years before). RESULTS: Positive influence of obesity was confirmed by the significant differences in BMD at lumbar spine, femoral neck (FN), and trochanter (TR) between the groups (p < 0.01). Age and years since menopause (YSM) were negatively correlated with BMD at all sites (p = 0.000). Comparing patients within 1 to < 6 YSM versus 6 to 10 YSM, BMD was higher in the former at LS and FN (p < 0.005), despite the higher BMI in the older group (p = 0.01). Obese patients had a lower prevalence of osteoporosis at LS and FN (p = 0.009). Regression analysis identified BMI as the strongest determinant of FN and TR BMD, while YSM was the strongest determinant of LS BMD. CONCLUSION: The protective effect of obesity is overtaken by age and estradiol deficiency. We recommend that even obese postmenopausal women should be screened for osteoporosis.
OBJECTIVE: To evaluate the influence of obesity, age, and years since menopause on bone density. METHODS: A retrospective analysis of bone mineral density (BMD) obtained from 588 women, 41 to 60 years, previously menopaused (1-10 years before). RESULTS: Positive influence of obesity was confirmed by the significant differences in BMD at lumbar spine, femoral neck (FN), and trochanter (TR) between the groups (p < 0.01). Age and years since menopause (YSM) were negatively correlated with BMD at all sites (p = 0.000). Comparing patients within 1 to < 6 YSM versus 6 to 10 YSM, BMD was higher in the former at LS and FN (p < 0.005), despite the higher BMI in the older group (p = 0.01). Obesepatients had a lower prevalence of osteoporosis at LS and FN (p = 0.009). Regression analysis identified BMI as the strongest determinant of FN and TR BMD, while YSM was the strongest determinant of LS BMD. CONCLUSION: The protective effect of obesity is overtaken by age and estradiol deficiency. We recommend that even obese postmenopausal women should be screened for osteoporosis.
Authors: G Rezende Yanagihara; R Carminati Shimano; J Atsuko Tida; J Suzuki Yamanaka; S Yasuyo Fukada; J P Mardegan Issa; A C Shimano; J M Tavares Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Wagner Luiz do Prado; Aline de Piano; Marise Lazaretti-Castro; Marco Túlio de Mello; Sérgio Garcia Stella; Sergio Tufik; Cláudia Maria Oller do Nascimento; Lila Missae Oyama; Mara Cristina Lofrano; Lian Tock; Danielle Arisa Caranti; Ana Raimunda Dâmaso Journal: J Bone Miner Metab Date: 2009-05-26 Impact factor: 2.626
Authors: Jennifer Stewart Williams; Paul Kowal; Heather Hestekin; Tristan O'Driscoll; Karl Peltzer; Alfred Yawson; Richard Biritwum; Tamara Maximova; Aarón Salinas Rodríguez; Betty Manrique Espinoza; Fan Wu; Perianayagam Arokiasamy; Somnath Chatterji Journal: BMC Med Date: 2015-06-23 Impact factor: 8.775