BACKGROUND: The incidence of H. pylori-negative, idiopathic peptic ulcer disease (IPUD) seems to be increasing with the changing trends of PUD and H. pylori infection in some developed countries. AIM: To investigate the changing trend of PUD and the prevalence ofH. pylori infection during the last decade and the prevalence of IPUD in Korea. METHODS: We prospectively evaluated H. pylori infection and the characteristics of PUD in 895 patients with newly diagnosed PUD from September 2004 to February 2005. RESULTS: The H. pylori infection rate in PUD was 72.0% and the proportion of IPUD was 22.2%. The proportion of gastric ulcer (GU) has significantly increased (47.8% vs. 44.3%) and the proportion of duodenal ulcer (DU) has significantly decreased (38.9% vs. 44.9%) compared with ten years ago. The changing trend in the prevalence of H. pylori infection in GU and DU showed an increase in GU (66.1% vs. 73.1%, P = 0.014) and a decrease in DU (79.3% vs. 68.1%, P = 0.001). CONCLUSION: Compared with our results of ten years ago, there has been a significant change in the distribution of PUD and in the prevalence of H. pylori infection in GU and DU. Patients with IPUD are not uncommon in Korea.
BACKGROUND: The incidence of H. pylori-negative, idiopathic peptic ulcer disease (IPUD) seems to be increasing with the changing trends of PUD and H. pyloriinfection in some developed countries. AIM: To investigate the changing trend of PUD and the prevalence ofH. pylori infection during the last decade and the prevalence of IPUD in Korea. METHODS: We prospectively evaluated H. pyloriinfection and the characteristics of PUD in 895 patients with newly diagnosed PUD from September 2004 to February 2005. RESULTS: The H. pyloriinfection rate in PUD was 72.0% and the proportion of IPUD was 22.2%. The proportion of gastric ulcer (GU) has significantly increased (47.8% vs. 44.3%) and the proportion of duodenal ulcer (DU) has significantly decreased (38.9% vs. 44.9%) compared with ten years ago. The changing trend in the prevalence of H. pyloriinfection in GU and DU showed an increase in GU (66.1% vs. 73.1%, P = 0.014) and a decrease in DU (79.3% vs. 68.1%, P = 0.001). CONCLUSION: Compared with our results of ten years ago, there has been a significant change in the distribution of PUD and in the prevalence of H. pyloriinfection in GU and DU. Patients with IPUD are not uncommon in Korea.
Authors: M Teresa Arroyo; Montse Forne; Carlos Martin de Argila; Faust Feu; Juan Arenas; Juan de la Vega; Vicente Garrigues; Francisco Mora; Manuel Castro; Luis Bujanda; Angel Cosme; Agustín Castiella; Javier P Gisbert; Antonio Hervas; Angel Lanas Journal: Helicobacter Date: 2004-06 Impact factor: 5.753